Detailed information of TA system TA079449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 169610..170135
• Replicon: plasmid pRM11060-2
• Accession: NZ_CP022660
• Organism: Salmonella enterica subsp. enterica strain RM11060

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A5J1SSZ4
• Locus tag: CGA23_RS26365
• Protein ID: WP_001159865.1
• Coordinates: 169830..170135 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: CGA23_RS26360
• Protein ID: WP_079953237.1
• Coordinates: 169610..169828 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGA23_RS26340	164809..165051	-	243	WP_057394653.1	type II toxin-antitoxin system ParD family antitoxin	-
CGA23_RS26345	165312..166277	+	966	WP_057394652.1	DNA-binding protein	-
CGA23_RS26350	166364..167131	+	768	WP_097361665.1	3'-5' exonuclease	-
CGA23_RS26355	167810..168898	-	1089	WP_097361622.1	transcriptional regulator	-
CGA23_RS26360	169610..169828	+	219	WP_079953237.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CGA23_RS26365	169830..170135	+	306	WP_001159865.1	type II toxin-antitoxin system toxin CcdB	Toxin
CGA23_RS26370	170137..170427	+	291	WP_097361623.1	cytoplasmic protein	-
CGA23_RS26375	170424..170960	+	537	Protein_182	cytoplasmic protein	-
CGA23_RS26380	170973..171755	+	783	WP_079953235.1	site-specific integrase	-
CGA23_RS26385	171905..172834	-	930	WP_057394647.1	Rpn family recombination-promoting nuclease/putative transposase	-
CGA23_RS26390	173249..174454	+	1206	WP_000427674.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..290957	290957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-105)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-40)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T79449 WP_001159865.1 NZ_CP022660:169830-170135 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T79449 NZ_CP022660:169830-170135 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT79449 WP_079953237.1 NZ_CP022660:169610-169828 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT79449 NZ_CP022660:169610-169828 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A5J1SSZ4