79445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4045037..4045642 Replicon chromosome
Accession NZ_CP022657
Organism Tumebacillus algifaecis strain THMBR28

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag CIG75_RS17935 Protein ID WP_087456648.1
Coordinates 4045037..4045387 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CIG75_RS17940 Protein ID WP_087459185.1
Coordinates 4045391..4045642 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIG75_RS17915 4040060..4040425 - 366 WP_094237889.1 VOC family protein -
CIG75_RS17920 4040532..4040984 - 453 WP_157729632.1 GNAT family N-acetyltransferase -
CIG75_RS17925 4041295..4043919 - 2625 WP_094237891.1 alanine--tRNA ligase -
CIG75_RS17930 4044660..4044932 + 273 WP_094237892.1 hypothetical protein -
CIG75_RS17935 4045037..4045387 - 351 WP_087456648.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CIG75_RS17940 4045391..4045642 - 252 WP_087459185.1 ribbon-helix-helix protein, CopG family Antitoxin
CIG75_RS17945 4045794..4046954 - 1161 WP_094237894.1 alanine racemase -
CIG75_RS17950 4047074..4048084 - 1011 WP_094237895.1 outer membrane lipoprotein-sorting protein -
CIG75_RS17955 4048224..4048607 - 384 WP_094237896.1 holo-ACP synthase -
CIG75_RS17960 4048604..4049005 - 402 WP_094237897.1 hotdog fold thioesterase -
CIG75_RS17970 4049622..4050452 + 831 WP_094237899.1 arylamine N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12917.91 Da        Isoelectric Point: 5.1342

>T79445 WP_087456648.1 NZ_CP022657:c4045387-4045037 [Tumebacillus algifaecis]
VNVKRGDIYFADLSPVVGSEQGGFRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGLDRDSVILLEQV
RTIDKQRLTDKITHLDDELMARVNESLMISLGLIEF

Download         Length: 351 bp

>T79445 NZ_CP022657:c4045387-4045037 [Tumebacillus algifaecis]
GTGAATGTAAAGCGCGGCGACATCTATTTTGCTGATTTATCGCCCGTCGTTGGTTCTGAGCAGGGCGGGTTTCGACCGGT
CCTCATCATCCAGAACGACATCGGCAATCGATTTAGTCCAACGGTGATTGTCGCGGCGATTACCGCGCAGATTCAAAAGG
CGAAGCTGCCAACCCATGTGGAAATAGACGCAAAAACTTACGGTTTGGATCGTGACTCCGTCATTCTGTTGGAGCAAGTC
CGCACAATCGATAAACAACGTTTGACCGATAAGATCACTCATCTCGACGATGAGCTGATGGCCAGGGTGAACGAGTCACT
GATGATATCCTTGGGGCTCATCGAGTTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9626.00 Da        Isoelectric Point: 4.6892

>AT79445 WP_087459185.1 NZ_CP022657:c4045642-4045391 [Tumebacillus algifaecis]
MVSVPNHLLQEVDGIVEKENLNRSEFIREAMNLYLQERKKRYIRESLQKGYLEMAKINLNIASEAFLAEEEAETTLDRLV
SGV

Download         Length: 252 bp

>AT79445 NZ_CP022657:c4045642-4045391 [Tumebacillus algifaecis]
ATGGTTAGTGTACCGAATCATCTGTTGCAGGAAGTGGACGGTATTGTGGAAAAGGAAAACCTGAACCGTAGCGAGTTCAT
CCGTGAGGCTATGAACCTGTACCTGCAAGAGAGAAAGAAGCGCTATATTCGGGAGTCGCTGCAAAAAGGCTATCTGGAAA
TGGCGAAGATTAACCTAAACATCGCATCAGAAGCGTTTTTGGCGGAGGAAGAGGCGGAGACAACTCTAGACCGTTTAGTT
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References