Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1523077..1523712 Replicon chromosome
Accession NZ_CP022655
Organism Paenibacillus sp. RUD330

Toxin (Protein)


Gene name mazF Uniprot ID W8YTZ1
Locus tag CIC07_RS06630 Protein ID WP_021877237.1
Coordinates 1523362..1523712 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0F5RA62
Locus tag CIC07_RS06625 Protein ID WP_048745833.1
Coordinates 1523077..1523358 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC07_RS06610 1518374..1519738 - 1365 WP_094248360.1 extracellular solute-binding protein -
CIC07_RS06615 1520333..1521508 + 1176 WP_076359479.1 outer membrane lipoprotein carrier protein LolA -
CIC07_RS06620 1521680..1522885 + 1206 WP_076359480.1 alanine racemase -
CIC07_RS06625 1523077..1523358 + 282 WP_048745833.1 CopG family ribbon-helix-helix protein Antitoxin
CIC07_RS06630 1523362..1523712 + 351 WP_021877237.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CIC07_RS06635 1523939..1524667 + 729 WP_076359481.1 flagellar biosynthesis protein FlgA -
CIC07_RS06640 1524664..1525500 + 837 WP_076359482.1 hypothetical protein -
CIC07_RS06645 1525497..1526984 + 1488 WP_083688689.1 CpaF family protein -
CIC07_RS06650 1526981..1527919 + 939 WP_076359483.1 type II secretion system F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12872.85 Da        Isoelectric Point: 5.5599

>T79444 WP_021877237.1 NZ_CP022655:1523362-1523712 [Paenibacillus sp. RUD330]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMRHVDDALQISVGLIDF

Download         Length: 351 bp

>T79444 NZ_CP022655:1523362-1523712 [Paenibacillus sp. RUD330]
TTGATCGTCAAACGCGGCGACGTATTCTTTGCAGACTTATCTCCCGTCGTAGGCTCCGAGCAAGGCGGCGTGCGCCCGGT
GCTTGTCCTTCAGAACGATATCGGCAACCGCTTCAGCCCGACGGTCATCGTAGCGGCCATTACGGCCCAGATCCAGAAGG
CGAAGCTTCCTACCCATGTTGAGATCGACGCCAAGGCTCATGGCTTCGATCGCGATTCGGTCATCCTGCTCGAGCAGATC
CGCACGATCGACAAGCAGCGCCTTACGGACAAGATCACGCATCTCGACGACGAGATGATGAGACATGTCGACGACGCGCT
GCAGATCAGCGTCGGTCTGATCGACTTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10703.38 Da        Isoelectric Point: 8.5543

>AT79444 WP_048745833.1 NZ_CP022655:1523077-1523358 [Paenibacillus sp. RUD330]
VANLQNTKRIMISIPDQLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRELMQRGYLEMAKINLNMASEAFHAEE
DADRALGRLVSGV

Download         Length: 282 bp

>AT79444 NZ_CP022655:1523077-1523358 [Paenibacillus sp. RUD330]
GTGGCCAATCTGCAGAATACCAAACGAATCATGATCAGTATCCCGGACCAGCTCCTTGAAGAAGTGGACGGAATCGTCGC
CAAAGAGAACTCCAACCGCAGCGAGTTCATCCGGCAGGCGATGAAACTTTACCTGGTGGAGCGCAAAAAACGTCAGATCC
GTGAATTGATGCAGCGCGGTTATCTGGAAATGGCTAAGATCAACTTGAACATGGCCTCGGAAGCTTTCCACGCGGAGGAA
GACGCAGACCGTGCGCTGGGCCGCCTCGTCAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229NV62

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5RA62

References