Detailed information of TA system TA079441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 1435436..1436352
• Replicon: chromosome
• Accession: NZ_CP022653
• Organism: Bacillus atrophaeus strain GQJK17

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A7U5BWH7
• Locus tag: BaGK_RS07245
• Protein ID: WP_003327423.1
• Coordinates: 1435606..1436352 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: -
• Locus tag: BaGK_RS07240
• Protein ID: WP_094231860.1
• Coordinates: 1435436..1435606 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BaGK_RS07210	1432263..1432592	+	330	WP_094231856.1	XkdW family protein	-
BaGK_RS07215	1432589..1432753	+	165	WP_094231857.1	XkdX family protein	-
BaGK_RS07220	1432797..1433636	+	840	WP_094233176.1	phage portal protein	-
BaGK_RS07225	1433689..1433958	+	270	WP_094231858.1	hemolysin XhlA family protein	-
BaGK_RS07230	1433971..1434234	+	264	WP_094231859.1	phage holin	-
BaGK_RS07235	1434247..1435140	+	894	WP_003327425.1	N-acetylmuramoyl-L-alanine amidase	-
BaGK_RS21540	1435216..1435338	-	123	WP_010788356.1	hypothetical protein	-
BaGK_RS07240	1435436..1435606	-	171	WP_094231860.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
BaGK_RS07245	1435606..1436352	-	747	WP_003327423.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BaGK_RS07250	1436461..1437459	-	999	WP_003327422.1	inorganic phosphate transporter	-
BaGK_RS07255	1437472..1438089	-	618	WP_003327421.1	DUF47 domain-containing protein	-
BaGK_RS07260	1438377..1439693	-	1317	WP_003327418.1	amino acid permease	-
BaGK_RS07265	1440112..1441062	+	951	WP_088116999.1	ring-cleaving dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-56)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29110.66 Da
• Isoelectric Point: 4.5650

>T79441 WP_003327423.1 NZ_CP022653:c1436352-1435606 [Bacillus atrophaeus]
MLLFFQIMVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALIDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG

Nucleotide

• Length: 747 bp

>T79441 NZ_CP022653:c1436352-1435606 [Bacillus atrophaeus]
ATGCTTTTATTCTTTCAGATTATGGTTTGGTGCATAATGGCCGCATTAGGCCTATACGTATATGCGGTGTGGCGGTTTGA
AGCAAAGGTGAAAGAAAAAATGTTTGCGATCCGGAAAACGTGGTATTTGATCTTTGTGATCGGCGCCATGGTATACTGGA
CGTATGACCCCTCTTCTCTTTTCAGGGAATGGACGAATTATTTGATTGTCGCTGTCAGCTTTGCTTTGATTGACGCCTTT
ATCTTTTTGAGCGCTTACGTAAAGAAACTTGCCGGCAATGAATTAGAAACCGACACACGGGAAATCCTTGAAGAAAACAA
TGAAATGCTCCACGTTTATCTTGATAAATTAAAAACGTACCAATACCTATTGAAAAATGAACCGATCCATGTTTATTATG
GAAGTATAGAAGCATACGCCGAGGGCATCGACAAGCTGCTCAAAACCTATGCCGACAAAATGAACTTAACGGCTTCGCTG
TGTGAATATTCGACACAGCTAGAAAAAGACCGCTTAACCGAGCATATGGATGATGCATTTGAGGTGCAGAGCCGGCTGGA
TCGAAAAGATGTATACTATGATCAGCACGGGAAGCTGGCACTCATCCCTTTTACAGTCCAGACACGCAGCTACGTCATCA
AGCTGGCGTCAGACAGCATTGTAACAGAATTTGATTATTTGCTTTTCACATCATTAACTAGCATTTACGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGACGGATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6621.63 Da
• Isoelectric Point: 11.0258

>AT79441 WP_094231860.1 NZ_CP022653:c1435606-1435436 [Bacillus atrophaeus]
MERAFQNDHSTRAAKPFKILKKRSITSVASYQVSPHTARIFKENERLIDEYKRKKA

Nucleotide

• Length: 171 bp

>AT79441 NZ_CP022653:c1435606-1435436 [Bacillus atrophaeus]
ATGGAACGTGCTTTTCAAAACGATCATTCGACCCGCGCGGCTAAACCGTTTAAGATATTAAAAAAGAGATCAATCACCAG
CGTCGCGAGCTATCAGGTCAGCCCCCACACGGCAAGAATTTTCAAAGAAAATGAGCGGCTGATTGACGAGTATAAAAGAA
AAAAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A7U5BWH7