Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 233985..234736 Replicon plasmid unnamed1
Accession NZ_CP022612
Organism Klebsiella pneumoniae strain CDC 0106

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag CHC10_RS28210 Protein ID WP_014386536.1
Coordinates 234254..234736 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag CHC10_RS28205 Protein ID WP_004902250.1
Coordinates 233985..234263 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHC10_RS28165 229628..230053 - 426 WP_000522996.1 organomercurial transporter MerC -
CHC10_RS28170 230081..230356 - 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
CHC10_RS28175 230372..230737 - 366 WP_004200999.1 mercuric ion transporter MerT -
CHC10_RS28180 230809..231264 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
CHC10_RS28185 231917..232375 + 459 WP_014386535.1 hypothetical protein -
CHC10_RS28195 233205..233546 + 342 WP_004902257.1 hypothetical protein -
CHC10_RS28200 233654..233866 + 213 WP_004902255.1 hypothetical protein -
CHC10_RS28205 233985..234263 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
CHC10_RS28210 234254..234736 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
CHC10_RS28225 235771..236309 + 539 Protein_254 hypothetical protein -
CHC10_RS28230 236414..236806 + 393 WP_032442757.1 hypothetical protein -
CHC10_RS28235 236907..237661 + 755 Protein_256 DUF2971 domain-containing protein -
CHC10_RS28240 237688..238335 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / aph(3')-VI / blaNDM-1 / blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / blaCTX-M-15 / aac(3)-IId / blaSHV-187 / ARR-3 / ere(A) / cmlA1 / aph(6)-Id / aph(3'')-Ib / sul2 - 1..334957 334957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T79438 WP_014386536.1 NZ_CP022612:234254-234736 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T79438 NZ_CP022612:234254-234736 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT79438 WP_004902250.1 NZ_CP022612:233985-234263 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT79438 NZ_CP022612:233985-234263 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References