79436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 86418..86940 Replicon plasmid unnamed1
Accession NZ_CP022612
Organism Klebsiella pneumoniae strain CDC 0106

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag CHC10_RS27220 Protein ID WP_038991638.1
Coordinates 86418..86702 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag CHC10_RS27225 Protein ID WP_004181777.1
Coordinates 86692..86940 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHC10_RS27190 81618..82713 + 1096 Protein_76 conjugal transfer protein TraG N-terminal domain-containing protein -
CHC10_RS27195 82812..83999 - 1188 WP_043907031.1 transposase -
CHC10_RS27200 84035..84463 + 429 WP_077256229.1 IS200/IS605 family transposase -
CHC10_RS27205 84542..84766 + 225 Protein_79 transposase -
CHC10_RS27210 85038..86264 - 1227 WP_080030933.1 transposase -
CHC10_RS27215 86300..86401 + 102 Protein_81 IS200/IS605 family transposase -
CHC10_RS27220 86418..86702 - 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHC10_RS27225 86692..86940 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CHC10_RS27230 87231..89030 + 1800 WP_043907032.1 ATP-dependent helicase -
CHC10_RS27235 89364..90350 + 987 WP_040120328.1 hypothetical protein -
CHC10_RS27240 90495..90848 + 354 WP_004181774.1 hypothetical protein -
CHC10_RS27245 90910..91731 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / aph(3')-VI / blaNDM-1 / blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / blaCTX-M-15 / aac(3)-IId / blaSHV-187 / ARR-3 / ere(A) / cmlA1 / aph(6)-Id / aph(3'')-Ib / sul2 - 1..334957 334957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T79436 WP_038991638.1 NZ_CP022612:c86702-86418 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T79436 NZ_CP022612:c86702-86418 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT79436 WP_004181777.1 NZ_CP022612:c86940-86692 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT79436 NZ_CP022612:c86940-86692 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References