Detailed information of TA system TA079412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2081874..2082388
• Replicon: chromosome
• Accession: NZ_CP022607
• Organism: Staphylococcus aureus strain FORC_061

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: FORC61_RS10715
• Protein ID: WP_114967493.1
• Coordinates: 2081874..2082083 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: W8UW13
• Locus tag: FORC61_RS10720
• Protein ID: WP_000138932.1
• Coordinates: 2082095..2082388 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC61_RS10695	2077382..2078740	-	1359	WP_000611470.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
FORC61_RS10700	2078755..2079825	-	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
FORC61_RS10705	2080143..2081345	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
FORC61_RS10710	2081609..2081746	-	138	WP_000828354.1	hypothetical protein	-
FORC61_RS10715	2081874..2082083	-	210	WP_114967493.1	heavy-metal-associated domain-containing protein	Toxin
FORC61_RS10720	2082095..2082388	-	294	WP_000138932.1	copper-sensing transcriptional repressor CsoR	Antitoxin
FORC61_RS10725	2082554..2084038	+	1485	WP_000571549.1	cardiolipin synthase	-
FORC61_RS10730	2084066..2084713	+	648	WP_001187630.1	HD domain-containing protein	-
FORC61_RS10740	2085185..2086057	-	873	WP_000725802.1	membrane protein insertase YidC	-
FORC61_RS10745	2086139..2086783	-	645	WP_000483154.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7873.80 Da
• Isoelectric Point: 4.1008

>T79412 WP_114967493.1 NZ_CP022607:c2082083-2081874 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMISVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T79412 NZ_CP022607:c2082083-2081874 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAAGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.82 Da
• Isoelectric Point: 6.2243

>AT79412 WP_000138932.1 NZ_CP022607:c2082388-2082095 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT79412 NZ_CP022607:c2082388-2082095 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: W8UW13