Detailed information of TA system TA079403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE(toxin)
• Location: 928507..929029
• Replicon: plasmid unnamed1
• Accession: NZ_CP022605
• Organism: [Ochrobactrum] quorumnocens strain A44

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: CES85_RS26605
• Protein ID: WP_095448745.1
• Coordinates: 928742..929029 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CES85_RS26600
• Protein ID: WP_095448744.1
• Coordinates: 928507..928752 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CES85_RS26570	924460..924762	+	303	WP_095448884.1	hypothetical protein	-
CES85_RS26575	924759..925133	+	375	WP_095448740.1	hypothetical protein	-
CES85_RS26580	925233..926081	+	849	WP_095448741.1	hypothetical protein	-
CES85_RS26585	926152..926364	+	213	WP_095448742.1	hypothetical protein	-
CES85_RS26595	927184..928176	-	993	WP_095448743.1	IS5 family transposase	-
CES85_RS26600	928507..928752	+	246	WP_095448744.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CES85_RS26605	928742..929029	+	288	WP_095448745.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CES85_RS26610	929462..929851	+	390	WP_095448746.1	hypothetical protein	-
CES85_RS27580	929848..930201	+	354	Protein_874	RES domain-containing protein	-
CES85_RS27585	930199..930741	+	543	Protein_875	IS110 family transposase	-
CES85_RS26620	930751..931878	-	1128	WP_095448748.1	VWA domain-containing protein	-
CES85_RS26625	932119..932508	+	390	WP_095444932.1	transposase	-
CES85_RS26630	932499..932900	+	402	WP_084486908.1	IS5 family transposase	-
CES85_RS26635	933033..933416	+	384	WP_095448749.1	pore-forming ESAT-6 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..1032012	1032012
	-	flank	IS/Tn	-	-	927184..928176	992

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-76)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11180.13 Da
• Isoelectric Point: 10.7097

>T79403 WP_095448745.1 NZ_CP022605:928742-929029 [[Ochrobactrum] quorumnocens]
MNYKLEIIPSARKEWDKLGSNIKEQFKKNLRERLVTPRLPSAALHGMKDHYKIKLRQLGYRLVYRVDDERVTILVVAVGK
RDKGDVYKVAKERAQ

Nucleotide

• Length: 288 bp

>T79403 NZ_CP022605:928742-929029 [[Ochrobactrum] quorumnocens]
ATGAACTATAAGCTTGAGATTATACCGTCCGCGCGAAAGGAGTGGGATAAACTCGGATCCAATATCAAAGAGCAGTTCAA
GAAGAATCTTCGTGAACGTCTCGTCACGCCACGACTGCCAAGTGCCGCACTTCATGGGATGAAAGACCACTACAAAATCA
AATTGCGTCAGCTTGGTTATCGCCTGGTTTATCGGGTGGACGACGAACGCGTGACTATTTTGGTCGTCGCGGTAGGTAAA
CGTGACAAGGGCGACGTATACAAAGTCGCAAAGGAGCGTGCACAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9035.35 Da
• Isoelectric Point: 4.4475

>AT79403 WP_095448744.1 NZ_CP022605:928507-928752 [[Ochrobactrum] quorumnocens]
MQRVEANVAVSVSDLKKSPSAVMEKAHGETVAVLNHNRIMAYMVPAELYEQMLERLDDLQLADVVLQRASEKGEPVNLDE
L

Nucleotide

• Length: 246 bp

>AT79403 NZ_CP022605:928507-928752 [[Ochrobactrum] quorumnocens]
ATGCAGCGTGTTGAAGCGAATGTGGCCGTCAGCGTGTCCGACCTTAAAAAAAGCCCTTCTGCGGTGATGGAAAAGGCGCA
TGGTGAAACCGTGGCTGTGCTGAATCACAATCGGATTATGGCATATATGGTGCCAGCAGAGCTCTATGAGCAAATGCTCG
AAAGATTAGACGACTTGCAGCTTGCAGACGTTGTCCTGCAGCGCGCGTCAGAAAAAGGCGAACCGGTAAATCTCGATGAA
CTATAA