Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_26
Location 1651610..1652248 Replicon chromosome
Accession NZ_CP022603
Organism [Ochrobactrum] quorumnocens strain A44

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CES85_RS07755 Protein ID WP_167388257.1
Coordinates 1651994..1652248 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CES85_RS07750 Protein ID WP_095445341.1
Coordinates 1651610..1651981 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES85_RS07725 1647732..1648112 - 381 WP_095445337.1 DUF853 family protein -
CES85_RS07730 1648141..1648575 - 435 WP_095445338.1 BrnA antitoxin family protein -
CES85_RS07735 1648682..1648951 + 270 Protein_1479 transposase -
CES85_RS07740 1649278..1650732 + 1455 WP_095445339.1 hypothetical protein -
CES85_RS07745 1650803..1651495 - 693 WP_095445340.1 ATP-binding domain-containing protein -
CES85_RS07750 1651610..1651981 - 372 WP_095445341.1 helix-turn-helix transcriptional regulator Antitoxin
CES85_RS07755 1651994..1652248 - 255 WP_167388257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CES85_RS07760 1652828..1653631 + 804 WP_157743427.1 hypothetical protein -
CES85_RS07765 1653806..1654468 - 663 WP_157743428.1 site-specific integrase -
CES85_RS27100 1654475..1654849 + 375 WP_167388258.1 hypothetical protein -
CES85_RS07770 1655053..1655241 + 189 WP_095445344.1 hypothetical protein -
CES85_RS07775 1655439..1656383 + 945 WP_095445345.1 aromatic alcohol reductase -
CES85_RS07780 1656509..1656943 - 435 WP_095445346.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1646521..1666181 19660
- inside IScluster/Tn - - 1657013..1661110 4097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(66-122)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9517.04 Da        Isoelectric Point: 10.0589

>T79395 WP_167388257.1 NZ_CP022603:c1652248-1651994 [[Ochrobactrum] quorumnocens]
MKQISYSREATTTLIKMPPNTAKLIRSKIEQYSNDPTSLTNNLKTLKGGEGLMRLRVGDWRIIFTEDGYILEIIKIAPRG
GAYE

Download         Length: 255 bp

>T79395 NZ_CP022603:c1652248-1651994 [[Ochrobactrum] quorumnocens]
ATGAAACAGATCAGCTATTCCCGCGAAGCAACTACGACCTTGATAAAGATGCCACCCAACACGGCGAAGCTGATCCGGTC
GAAAATCGAACAGTACTCCAACGATCCTACTAGCCTGACTAATAACCTTAAAACGCTTAAGGGCGGGGAAGGCTTGATGC
GCCTGCGGGTCGGTGACTGGCGCATCATCTTCACGGAAGATGGCTACATTCTAGAGATTATAAAGATAGCGCCGCGTGGC
GGCGCTTACGAATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13645.51 Da        Isoelectric Point: 4.4184

>AT79395 WP_095445341.1 NZ_CP022603:c1651981-1651610 [[Ochrobactrum] quorumnocens]
MNVQIINTPQGEEMAVLPKADYDKLLEAFEDREDIEAGRKFRAKLSAGDEELIPSEYVNRMIDGENKIKVWRDFRGMSAK
ALADAAGMSAPYLSQIESGAREGSLDALKKLAEALRVTIDELV

Download         Length: 372 bp

>AT79395 NZ_CP022603:c1651981-1651610 [[Ochrobactrum] quorumnocens]
ATGAACGTTCAAATCATCAATACACCACAGGGGGAGGAAATGGCAGTCCTTCCCAAGGCCGACTATGACAAGCTGCTCGA
AGCTTTTGAAGATCGCGAAGACATTGAAGCTGGTCGCAAGTTCCGCGCAAAACTGTCCGCTGGCGACGAAGAATTGATCC
CGTCCGAGTACGTCAACCGCATGATCGACGGCGAGAACAAAATTAAGGTTTGGCGTGACTTTCGCGGAATGAGCGCTAAA
GCACTCGCCGACGCTGCCGGTATGAGCGCGCCCTACCTCTCGCAAATTGAAAGCGGCGCTCGCGAAGGCTCGCTCGATGC
TTTGAAAAAGCTTGCAGAAGCGCTCAGGGTCACAATAGACGAGCTAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References