Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 639227..639849 Replicon chromosome
Accession NZ_CP022603
Organism [Ochrobactrum] quorumnocens strain A44

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CES85_RS03100 Protein ID WP_095444593.1
Coordinates 639227..639586 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CES85_RS03105 Protein ID WP_095444594.1
Coordinates 639586..639849 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES85_RS03080 634383..635591 - 1209 WP_095444590.1 acetyl-CoA C-acetyltransferase -
CES85_RS03085 635655..637448 - 1794 WP_095444591.1 acyl-CoA dehydrogenase C-terminal domain-containing protein -
CES85_RS03090 637978..638741 + 764 Protein_581 IS5 family transposase -
CES85_RS03095 638738..638932 + 195 WP_095444592.1 hypothetical protein -
CES85_RS03100 639227..639586 - 360 WP_095444593.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CES85_RS03105 639586..639849 - 264 WP_095444594.1 PbsX family transcriptional regulator Antitoxin
CES85_RS03110 640060..640266 - 207 WP_157743393.1 ribbon-helix-helix protein, CopG family -
CES85_RS03115 640476..640751 - 276 WP_095444596.1 transposase -
CES85_RS03120 640842..642398 - 1557 WP_095444597.1 ISL3 family transposase -
CES85_RS03125 642500..643291 - 792 WP_095444598.1 IS21-like element helper ATPase IstB -
CES85_RS03130 643281..643829 - 549 Protein_589 IS21 family transposase -
CES85_RS03135 644112..644483 - 372 WP_095444599.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 638346..643808 5462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12906.11 Da        Isoelectric Point: 8.3094

>T79394 WP_095444593.1 NZ_CP022603:c639586-639227 [[Ochrobactrum] quorumnocens]
MVRSNIPKRGDVFLVDLNPVVGNEMRDAHRCVVITPHEINMVGMCLTVPITTGGAFTRKVGLAVNISGHKTTGVALCNQV
RALDILERMKQKTAKHIDTLDASTTDEIVARVVSMIDPA

Download         Length: 360 bp

>T79394 NZ_CP022603:c639586-639227 [[Ochrobactrum] quorumnocens]
ATGGTTCGGAGTAACATTCCAAAGCGTGGTGACGTCTTTCTCGTCGACCTTAATCCTGTTGTAGGCAATGAAATGAGGGA
TGCTCATCGCTGTGTCGTAATCACGCCTCATGAAATCAATATGGTCGGCATGTGCCTTACGGTTCCCATTACAACGGGCG
GCGCATTCACCCGCAAAGTCGGTCTTGCCGTTAATATCTCAGGACACAAAACGACTGGTGTGGCTCTCTGCAATCAGGTG
AGAGCACTCGACATCTTGGAGCGGATGAAGCAAAAGACTGCCAAGCATATCGACACGTTGGACGCCTCCACCACTGACGA
AATTGTTGCCAGAGTGGTCAGCATGATCGACCCTGCTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9186.68 Da        Isoelectric Point: 9.8677

>AT79394 WP_095444594.1 NZ_CP022603:c639849-639586 [[Ochrobactrum] quorumnocens]
MSNTAKIRRQGGATVFSIPPALLKMLGVEVGAELTLVVNNGSLVATPKQGKKRYTMAEMLEGANELVALNKEAASWNVSA
PVGNEVF

Download         Length: 264 bp

>AT79394 NZ_CP022603:c639849-639586 [[Ochrobactrum] quorumnocens]
ATGAGCAACACTGCAAAGATTCGCCGTCAGGGTGGTGCGACCGTATTTAGCATTCCTCCCGCGCTTTTGAAGATGCTTGG
CGTCGAAGTCGGCGCAGAGTTGACCTTGGTTGTCAATAATGGGTCTCTTGTGGCGACCCCGAAACAGGGGAAGAAAAGAT
ACACGATGGCTGAGATGCTAGAAGGAGCCAATGAATTAGTAGCGCTCAATAAAGAAGCCGCATCCTGGAATGTTAGTGCG
CCCGTCGGTAACGAAGTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References