Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 838115..839355 Replicon chromosome
Accession NZ_CP022601
Organism Streptococcus pluranimalium strain 14A0014

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag Sp14A_RS04470 Protein ID WP_115130080.1
Coordinates 838591..839355 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag Sp14A_RS04465 Protein ID WP_115130079.1
Coordinates 838115..838591 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sp14A_RS04435 833842..835473 + 1632 WP_115130075.1 relaxase/mobilization nuclease domain-containing protein -
Sp14A_RS04440 835470..836131 + 662 Protein_823 ParB N-terminal domain-containing protein -
Sp14A_RS04450 836873..837169 + 297 WP_115130076.1 Arc family DNA-binding protein -
Sp14A_RS04455 837163..837501 + 339 WP_115130077.1 type II toxin-antitoxin system RelE/ParE family toxin -
Sp14A_RS04460 837684..837869 + 186 WP_115130078.1 hypothetical protein -
Sp14A_RS04465 838115..838591 + 477 WP_115130079.1 helix-turn-helix domain-containing protein Antitoxin
Sp14A_RS04470 838591..839355 + 765 WP_115130080.1 zeta toxin family protein Toxin
Sp14A_RS04475 839405..840691 + 1287 WP_115130081.1 SIR2 family protein -
Sp14A_RS04480 840684..842369 + 1686 WP_115130082.1 ATP-binding protein -
Sp14A_RS04485 842655..843760 + 1106 WP_115129601.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 760006..890531 130525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29305.54 Da        Isoelectric Point: 7.1069

>T79392 WP_115130080.1 NZ_CP022601:838591-839355 [Streptococcus pluranimalium]
MSLEAFRQDDFDLALKRTIRSLTRGKTTSVRPKAILLGGQSGAGKATIHRIKQKEFRGNIIIIDGDSYRSLHPNYLALQE
IYGKDSVDYTKGFAVQMVEHLVEELSKKGYHLLIEGTLRTTEVPRQTALLLCSRNYKVYLAVMATKPELSYLRTLIRYEE
VYVVNPSQARATPKDHHDGVVENLVNNLRELERDQLFDQIHIYQRDRACIYDSETIEGAAAEVLQECLFGKWSKVEEEML
KVEQERLREMQELK

Download         Length: 765 bp

>T79392 NZ_CP022601:838591-839355 [Streptococcus pluranimalium]
ATGAGTTTAGAAGCATTTAGACAAGATGACTTTGATCTAGCCTTAAAACGGACTATTCGTTCCTTAACTCGTGGGAAAAC
GACATCAGTTAGACCAAAAGCAATTTTACTTGGTGGGCAAAGCGGAGCCGGGAAGGCGACCATTCATCGGATTAAGCAAA
AAGAATTTCGAGGCAATATCATCATTATTGATGGGGATAGTTATCGCTCCCTGCATCCCAATTATTTGGCTTTACAGGAA
ATCTATGGCAAGGATAGTGTGGATTATACAAAAGGATTTGCGGTGCAAATGGTCGAACATCTGGTTGAAGAGTTGAGTAA
GAAAGGATATCACTTACTCATCGAAGGAACCTTGAGGACGACAGAGGTTCCCCGACAAACAGCTCTGCTATTATGCTCAA
GAAACTACAAGGTTTATCTTGCCGTTATGGCGACCAAGCCAGAGTTGTCCTACCTCAGAACCTTAATCCGTTATGAAGAA
GTTTACGTAGTTAATCCAAGTCAGGCTAGAGCAACCCCCAAAGACCACCATGATGGGGTTGTAGAGAATTTGGTTAATAA
CCTAAGAGAGTTAGAAAGAGATCAACTCTTTGACCAGATTCATATTTATCAAAGAGATAGGGCTTGTATCTATGATTCTG
AAACCATTGAAGGGGCAGCAGCAGAAGTTCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTTGAGGAGGAGATGCTT
AAAGTGGAGCAGGAACGGTTGAGGGAGATGCAAGAATTGAAGTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18225.47 Da        Isoelectric Point: 4.2757

>AT79392 WP_115130079.1 NZ_CP022601:838115-838591 [Streptococcus pluranimalium]
MIGDNIKSLRRTHDLTQPEFAEIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKILTPVEDYQLTLKIE
IIKERGAAILSDLYRYQDSQRLAFDDETNPWILMSDDLSDLINTKIYLVDTFDEVERYNGYLDGIERVLDLARHQVVT

Download         Length: 477 bp

>AT79392 NZ_CP022601:838115-838591 [Streptococcus pluranimalium]
ATGATTGGAGATAATATCAAATCGTTACGCAGAACCCATGATTTGACGCAACCAGAGTTTGCAGAGATAGTGGGAATCTC
ACGGAATAGTCTTAGCCGTTATGAGAATGGAACCAGCTCTGTTTCAACAGAGCTGATAGACCGTATTTGTCAGAAGTTCA
ACGTATCCTATGTTGATATTGTAGGAGAGGATAAGATATTGACACCAGTAGAAGATTATCAATTGACGCTGAAAATCGAA
ATCATCAAAGAACGTGGTGCAGCTATTTTATCTGATCTATATCGCTATCAAGATAGTCAAAGACTTGCTTTTGATGATGA
GACTAATCCTTGGATTTTGATGAGTGATGACTTGTCGGATCTTATTAATACCAAGATTTATCTTGTTGATACTTTTGATG
AAGTGGAGCGGTACAATGGTTATTTGGATGGTATTGAGCGCGTGTTGGATCTTGCCCGTCATCAGGTGGTGACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References