Detailed information of TA system TA079391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 680183..680856
• Replicon: chromosome
• Accession: NZ_CP022601
• Organism: Streptococcus pluranimalium strain 14A0014

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: V6Z2K9
• Locus tag: Sp14A_RS03640
• Protein ID: WP_015647112.1
• Coordinates: 680183..680365 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: Sp14A_RS03645
• Protein ID: WP_115129953.1
• Coordinates: 680404..680856 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Sp14A_RS03600	675209..676057	+	849	WP_115129947.1	ATP-binding protein	-
Sp14A_RS03605	676480..676662	+	183	WP_115129948.1	hypothetical protein	-
Sp14A_RS03610	676760..677338	+	579	WP_115129949.1	hypothetical protein	-
Sp14A_RS03615	677335..677622	+	288	WP_115129950.1	hypothetical protein	-
Sp14A_RS03620	677661..678056	+	396	WP_027971718.1	hypothetical protein	-
Sp14A_RS03625	678031..678282	+	252	WP_162797742.1	hypothetical protein	-
Sp14A_RS03630	678335..679440	+	1106	WP_115129601.1	IS3 family transposase	-
Sp14A_RS03635	679650..680066	+	417	WP_115129952.1	hypothetical protein	-
Sp14A_RS03640	680183..680365	+	183	WP_015647112.1	type II toxin-antitoxin system HicA family toxin	Toxin
Sp14A_RS03645	680404..680856	+	453	WP_115129953.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Sp14A_RS03650	680969..681178	+	210	WP_115129954.1	hypothetical protein	-
Sp14A_RS03655	681958..684588	+	2631	WP_115129955.1	GBS Bsp-like repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	670770..687234	16464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-77)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6630.84 Da
• Isoelectric Point: 10.8207

>T79391 WP_015647112.1 NZ_CP022601:680183-680365 [Streptococcus pluranimalium]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T79391 NZ_CP022601:680183-680365 [Streptococcus pluranimalium]
ATGCCTATGACACAAAAAGAAATGGTTAAACTTCTTACCGCCAACGGTTGGACAAAGACCAAAGGAGGTAAAGGGTCACA
CGTTAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACTGAACGGGGCATTA
AAAAGCAAGCTGGGCTGTTATAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16691.64 Da
• Isoelectric Point: 3.8422

>AT79391 WP_115129953.1 NZ_CP022601:680404-680856 [Streptococcus pluranimalium]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGINLADYIENGRDIPTPSPINTLSLADNNPF
RDDEDIELIYDPSKSFISMVMVDVADYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 453 bp

>AT79391 NZ_CP022601:680404-680856 [Streptococcus pluranimalium]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGACGATACAGACGGAGCTAACGCCCCTTACTTTGTCACTTTCCCAGA
TTTTGAACATTCAGCAACTCAAGGTGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGTATTAACCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCACACCTTCCCCTATTAACACCTTATCTTTAGCAGATAATAACCCTTTC
CGTGATGATGAGGATATAGAGCTTATCTATGACCCTAGTAAGTCTTTTATTTCTATGGTTATGGTTGATGTCGCCGATTA
TTTAGGCAGTCAAGAACCTATAAAGAAAACTCTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGCTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCTGATAAAAAAATTCATGCTTAA

Structures

Toxin

• AlphaFold DB: V6Z2K9