Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2619227..2619750 Replicon chromosome
Accession NZ_CP022582
Organism Staphylococcus aureus strain FORC_062

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FORC62_RS13820 Protein ID WP_114914780.1
Coordinates 2619227..2619493 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag FORC62_RS13825 Protein ID WP_000587616.1
Coordinates 2619493..2619750 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC62_RS13800 2614534..2615721 - 1188 WP_000026189.1 MFS transporter -
FORC62_RS13805 2616117..2616893 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
FORC62_RS13810 2616886..2617548 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
FORC62_RS13815 2617796..2618872 - 1077 WP_001076673.1 M42 family metallopeptidase -
FORC62_RS13820 2619227..2619493 - 267 WP_114914780.1 Txe/YoeB family addiction module toxin Toxin
FORC62_RS13825 2619493..2619750 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC62_RS13835 2620109..2620564 + 456 WP_000732076.1 DUF1307 domain-containing protein -
FORC62_RS13840 2620732..2622309 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
FORC62_RS13845 2622504..2623253 + 750 WP_000072461.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10694.28 Da        Isoelectric Point: 10.1597

>T79387 WP_114914780.1 NZ_CP022582:c2619493-2619227 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKMTQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T79387 NZ_CP022582:c2619493-2619227 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATGACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT79387 WP_000587616.1 NZ_CP022582:c2619750-2619493 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT79387 NZ_CP022582:c2619750-2619493 [Staphylococcus aureus]
ATGATTATCACTAGTCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References