Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 879776..880253 Replicon chromosome
Accession NZ_CP022582
Organism Staphylococcus aureus strain FORC_062

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC62_RS04380 Protein ID WP_000052076.1
Coordinates 879776..879964 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC62_RS04385 Protein ID WP_001059690.1
Coordinates 879993..880253 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC62_RS04350 875782..876291 + 510 WP_114914761.1 hypothetical protein -
FORC62_RS04355 876632..877318 + 687 WP_000141557.1 thermonuclease family protein -
FORC62_RS04360 877675..877875 + 201 WP_001059082.1 cold-shock protein -
FORC62_RS04365 878367..878585 - 219 WP_000005886.1 hypothetical protein -
FORC62_RS04370 878647..878931 - 285 WP_044423470.1 hypothetical protein -
FORC62_RS04375 879019..879588 - 570 WP_001106654.1 hypothetical protein -
FORC62_RS04380 879776..879964 - 189 WP_000052076.1 hypothetical protein Toxin
FORC62_RS04385 879993..880253 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC62_RS04390 880594..880797 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC62_RS04395 880794..881030 - 237 WP_063456452.1 hypothetical protein -
FORC62_RS04400 881255..881836 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FORC62_RS04405 881909..882526 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FORC62_RS04410 882681..883175 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC62_RS04415 883574..883996 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC62_RS04420 884144..884860 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79373 WP_000052076.1 NZ_CP022582:c879964-879776 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79373 NZ_CP022582:c879964-879776 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79373 WP_001059690.1 NZ_CP022582:c880253-879993 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79373 NZ_CP022582:c880253-879993 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References