Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 4135172..4135878 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag CHR52_RS20260 Protein ID WP_003417998.1
Coordinates 4135172..4135582 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5R1Z4U0
Locus tag CHR52_RS20265 Protein ID WP_003911013.1
Coordinates 4135579..4135878 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS20245 4130611..4132200 + 1590 WP_003901630.1 IMP dehydrogenase -
CHR52_RS20250 4132220..4133347 + 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
CHR52_RS20255 4133403..4135139 + 1737 WP_003418002.1 cholesterol oxidase -
CHR52_RS20260 4135172..4135582 - 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR52_RS20265 4135579..4135878 - 300 WP_003911013.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CHR52_RS20270 4135913..4136800 - 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
CHR52_RS20275 4136862..4137428 + 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
CHR52_RS20280 4137546..4138250 + 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
CHR52_RS20285 4138267..4139868 + 1602 WP_003417969.1 FAD/NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-65)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T79369 WP_003417998.1 NZ_CP022578:c4135582-4135172 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T79369 NZ_CP022578:c4135582-4135172 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10956.61 Da        Isoelectric Point: 9.2278

>AT79369 WP_003911013.1 NZ_CP022578:c4135878-4135579 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGCKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT79369 NZ_CP022578:c4135878-4135579 [Mycobacterium tuberculosis]
ATGCGTGCTACCGTTGGGCTTGTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGT
TGAAGCCGGCGAGGAACTTGGCGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTT
CTCGCGAAGCCCTGATTGAATCAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCG
GCGCGCGGCTGCAAGCGCACCCTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure
AlphaFold DB A0A5R1Z4U0

References