Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2844944..2845587 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag CHR52_RS14195 Protein ID WP_003403187.1
Coordinates 2844944..2845345 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag CHR52_RS14200 Protein ID WP_003403184.1
Coordinates 2845342..2845587 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS14165 2841902..2842507 - 606 WP_003898526.1 hypothetical protein -
CHR52_RS14170 2842649..2842870 + 222 WP_003898525.1 DUF4926 domain-containing protein -
CHR52_RS14175 2842922..2844079 + 1158 WP_003898524.1 hypothetical protein -
CHR52_RS14180 2844159..2844356 + 198 WP_003403191.1 hypothetical protein -
CHR52_RS21615 2844389..2844556 + 168 WP_077385191.1 DUF3800 domain-containing protein -
CHR52_RS14190 2844774..2845001 - 228 WP_003900974.1 hypothetical protein -
CHR52_RS14195 2844944..2845345 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR52_RS14200 2845342..2845587 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CHR52_RS14205 2845632..2846018 - 387 WP_003403180.1 hypothetical protein -
CHR52_RS14210 2846072..2846815 - 744 WP_003403177.1 IS607 family element transposase accessory protein TnpB -
CHR52_RS14215 2846817..2847401 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
CHR52_RS14220 2847642..2848592 - 951 WP_003900184.1 DUF1259 domain-containing protein -
CHR52_RS14225 2848664..2848975 - 312 WP_003403164.1 hypothetical protein -
CHR52_RS14230 2849032..2849793 + 762 WP_003403148.1 two-component system response regulator TcrA -
CHR52_RS14235 2849837..2850307 + 471 WP_003403144.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T79358 WP_003403187.1 NZ_CP022578:c2845345-2844944 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T79358 NZ_CP022578:c2845345-2844944 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT79358 WP_003403184.1 NZ_CP022578:c2845587-2845342 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT79358 NZ_CP022578:c2845587-2845342 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References