Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2794657..2795290 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag CHR52_RS13910 Protein ID WP_003403365.1
Coordinates 2794907..2795290 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag CHR52_RS13905 Protein ID WP_003403368.1
Coordinates 2794657..2794812 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS13875 2789774..2792137 - 2364 WP_003901895.1 arylsulfatase AtsD -
CHR52_RS13880 2792251..2792505 + 255 WP_003911263.1 antitoxin VapB7 -
CHR52_RS13885 2792502..2792939 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
CHR52_RS13890 2793049..2793294 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
CHR52_RS13895 2793281..2793589 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
CHR52_RS13900 2793865..2794581 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
CHR52_RS13905 2794657..2794812 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CHR52_RS13910 2794907..2795290 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
CHR52_RS13915 2795678..2796688 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
CHR52_RS13920 2796769..2798274 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
CHR52_RS13925 2798345..2799040 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
CHR52_RS13930 2799033..2799425 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
CHR52_RS13935 2799462..2799998 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T79354 WP_003403365.1 NZ_CP022578:2794907-2795290 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T79354 NZ_CP022578:2794907-2795290 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT79354 WP_003403368.1 NZ_CP022578:2794657-2794812 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT79354 NZ_CP022578:2794657-2794812 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References