Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 2792502..2793294 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag CHR52_RS13885 Protein ID WP_003403386.1
Coordinates 2792502..2792939 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag CHR52_RS13890 Protein ID WP_003403381.1
Coordinates 2793049..2793294 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS13860 2788965..2789138 - 174 WP_003898549.1 hypothetical protein -
CHR52_RS13865 2789135..2789473 - 339 WP_003403405.1 PIN domain-containing protein -
CHR52_RS13870 2789385..2789711 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CHR52_RS13875 2789774..2792137 - 2364 WP_003901895.1 arylsulfatase AtsD -
CHR52_RS13880 2792251..2792505 + 255 WP_003911263.1 antitoxin VapB7 -
CHR52_RS13885 2792502..2792939 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR52_RS13890 2793049..2793294 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
CHR52_RS13895 2793281..2793589 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
CHR52_RS13900 2793865..2794581 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
CHR52_RS13905 2794657..2794812 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
CHR52_RS13910 2794907..2795290 + 384 WP_003403365.1 ribonuclease VapC6 -
CHR52_RS13915 2795678..2796688 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
CHR52_RS13920 2796769..2798274 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T79352 WP_003403386.1 NZ_CP022578:2792502-2792939 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T79352 NZ_CP022578:2792502-2792939 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT79352 WP_003403381.1 NZ_CP022578:2793049-2793294 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT79352 NZ_CP022578:2793049-2793294 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References