Detailed information of TA system TA079346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2308474..2309042
• Replicon: chromosome
• Accession: NZ_CP022578
• Organism: Mycobacterium tuberculosis strain WC059

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TH08
• Locus tag: CHR52_RS11325
• Protein ID: WP_003405865.1
• Coordinates: 2308474..2308848 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TH07
• Locus tag: CHR52_RS11330
• Protein ID: WP_003405863.1
• Coordinates: 2308845..2309042 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHR52_RS11295	2304824..2305594	+	771	Protein_2139	adenylate/guanylate cyclase domain-containing protein	-
CHR52_RS11300	2305627..2306487	+	861	WP_003898734.1	hypothetical protein	-
CHR52_RS11305	2306502..2306825	-	324	WP_003405871.1	antibiotic biosynthesis monooxygenase	-
CHR52_RS11310	2307068..2307343	+	276	WP_003405867.1	hypothetical protein	-
CHR52_RS11315	2307270..2307455	-	186	WP_003901093.1	hypothetical protein	-
CHR52_RS11320	2307573..2308271	-	699	WP_003898733.1	hypothetical protein	-
CHR52_RS11325	2308474..2308848	-	375	WP_003405865.1	type II toxin-antitoxin system VapC family toxin	Toxin
CHR52_RS11330	2308845..2309042	-	198	WP_003405863.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CHR52_RS11335	2309130..2310203	-	1074	WP_003898732.1	redox-regulated ATPase YchF	-
CHR52_RS11340	2310266..2311249	+	984	WP_003898731.1	hypothetical protein	-
CHR52_RS11345	2311266..2312273	-	1008	WP_003405853.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
CHR52_RS11350	2312363..2313001	+	639	WP_003898730.1	lipid droplet-associated protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13444.56 Da
• Isoelectric Point: 5.1881

>T79346 WP_003405865.1 NZ_CP022578:c2308848-2308474 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Nucleotide

• Length: 375 bp

>T79346 NZ_CP022578:c2308848-2308474 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6973.03 Da
• Isoelectric Point: 11.7327

>AT79346 WP_003405863.1 NZ_CP022578:c2309042-2308845 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Nucleotide

• Length: 198 bp

>AT79346 NZ_CP022578:c2309042-2308845 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0TH08

Antitoxin

• AlphaFold DB: G0TH07