Detailed information of TA system TA079345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2162130..2162818
• Replicon: chromosome
• Accession: NZ_CP022578
• Organism: Mycobacterium tuberculosis strain WC059

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: CHR52_RS10620
• Protein ID: WP_003406304.1
• Coordinates: 2162130..2162561 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: CHR52_RS10625
• Protein ID: WP_003406302.1
• Coordinates: 2162558..2162818 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHR52_RS10590	2157957..2158226	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CHR52_RS10595	2158223..2158516	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
CHR52_RS10600	2158573..2159403	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
CHR52_RS10605	2159484..2160344	-	861	WP_003900301.1	hypothetical protein	-
CHR52_RS10615	2160524..2162107	+	1584	WP_009940130.1	PE family protein	-
CHR52_RS10620	2162130..2162561	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
CHR52_RS10625	2162558..2162818	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
CHR52_RS10630	2162894..2163883	-	990	WP_003406301.1	malate dehydrogenase	-
CHR52_RS10635	2164054..2165154	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
CHR52_RS10640	2165231..2166412	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
CHR52_RS10645	2166417..2167241	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T79345 WP_003406304.1 NZ_CP022578:c2162561-2162130 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T79345 NZ_CP022578:c2162561-2162130 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT79345 WP_003406302.1 NZ_CP022578:c2162818-2162558 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT79345 NZ_CP022578:c2162818-2162558 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6