Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1778428..1779056 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag CHR52_RS08835 Protein ID WP_003407786.1
Coordinates 1778428..1778832 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLU3
Locus tag CHR52_RS08840 Protein ID WP_003407785.1
Coordinates 1778838..1779056 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS08825 1774379..1776676 + 2298 WP_003407790.1 malto-oligosyltrehalose synthase -
CHR52_RS08830 1776669..1778411 + 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
CHR52_RS08835 1778428..1778832 - 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
CHR52_RS08840 1778838..1779056 - 219 WP_003407785.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CHR52_RS08845 1779094..1780383 - 1290 WP_003407781.1 threonine ammonia-lyase -
CHR52_RS08850 1780418..1780864 - 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
CHR52_RS08855 1780874..1782067 - 1194 WP_003901197.1 MMPL family transporter -
CHR52_RS08860 1782206..1782814 - 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
CHR52_RS08865 1782882..1783259 - 378 WP_003407771.1 fumarate reductase subunit FrdD -
CHR52_RS08870 1783256..1783636 - 381 WP_003407768.1 fumarate reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-49)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T79341 WP_003407786.1 NZ_CP022578:c1778832-1778428 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T79341 NZ_CP022578:c1778832-1778428 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8209.32 Da        Isoelectric Point: 4.5600

>AT79341 WP_003407785.1 NZ_CP022578:c1779056-1778838 [Mycobacterium tuberculosis]
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 219 bp

>AT79341 NZ_CP022578:c1779056-1778838 [Mycobacterium tuberculosis]
GTGTATCGTTGGTGTATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCT
GACCACCAAGAGGGCGGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGC
TGGAAGGCGTCGGCTGGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
PDB 6A7V
AlphaFold DB P9WLU3

References