Detailed information of TA system TA079338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1364162..1364865
• Replicon: chromosome
• Accession: NZ_CP022578
• Organism: Mycobacterium tuberculosis strain WC059

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: G0TLK7
• Locus tag: CHR52_RS06925
• Protein ID: WP_003409778.1
• Coordinates: 1364536..1364865 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TLK8
• Locus tag: CHR52_RS06920
• Protein ID: WP_003409780.1
• Coordinates: 1364162..1364539 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHR52_RS06880	1359317..1359508	+	192	WP_003409876.1	hypothetical protein	-
CHR52_RS06885	1359529..1360431	+	903	WP_003899097.1	hypothetical protein	-
CHR52_RS06890	1360442..1360792	+	351	WP_106420779.1	hypothetical protein	-
CHR52_RS06895	1360906..1361088	+	183	WP_003409870.1	hypothetical protein	-
CHR52_RS06900	1361081..1361482	-	402	WP_003409869.1	hypothetical protein	-
CHR52_RS06905	1361549..1362001	+	453	WP_003899095.1	lipoprotein	-
CHR52_RS06910	1362156..1363520	-	1365	WP_003903691.1	HNH endonuclease	-
CHR52_RS06915	1363575..1364165	+	591	WP_003409784.1	SEC-C domain-containing protein	-
CHR52_RS06920	1364162..1364539	+	378	WP_003409780.1	type II toxin-antitoxin system antitoxin MazE5	Antitoxin
CHR52_RS06925	1364536..1364865	+	330	WP_003409778.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CHR52_RS06930	1365075..1365845	-	771	WP_003409775.1	SDR family oxidoreductase	-
CHR52_RS06935	1365842..1366903	-	1062	WP_003899092.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
CHR52_RS06940	1366900..1367415	-	516	WP_003409718.1	flavin reductase family protein	-
CHR52_RS06945	1367412..1368482	-	1071	WP_003902252.1	epoxide hydrolase EphB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11787.82 Da
• Isoelectric Point: 8.5361

>T79338 WP_003409778.1 NZ_CP022578:1364536-1364865 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Nucleotide

• Length: 330 bp

>T79338 NZ_CP022578:1364536-1364865 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13560.07 Da
• Isoelectric Point: 5.1519

>AT79338 WP_003409780.1 NZ_CP022578:1364162-1364539 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Nucleotide

• Length: 378 bp

>AT79338 NZ_CP022578:1364162-1364539 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: G0TLK7

Antitoxin

• AlphaFold DB: G0TLK8