Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1355281..1355825 | Replicon | chromosome |
| Accession | NZ_CP022578 | ||
| Organism | Mycobacterium tuberculosis strain WC059 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CHR52_RS06835 | Protein ID | WP_003409896.1 |
| Coordinates | 1355529..1355825 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CHR52_RS06830 | Protein ID | WP_003409899.1 |
| Coordinates | 1355281..1355532 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CHR52_RS06795 | 1351008..1351805 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
| CHR52_RS06810 | 1352704..1353924 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| CHR52_RS06815 | 1353957..1354229 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CHR52_RS06820 | 1354233..1354640 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| CHR52_RS06825 | 1354800..1355294 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| CHR52_RS06830 | 1355281..1355532 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CHR52_RS06835 | 1355529..1355825 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CHR52_RS06840 | 1355874..1356488 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| CHR52_RS06845 | 1356377..1356922 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| CHR52_RS06850 | 1356919..1357368 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CHR52_RS06855 | 1357410..1357787 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| CHR52_RS21765 | 1357762..1358283 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| CHR52_RS06865 | 1358257..1358568 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CHR52_RS06870 | 1358565..1358780 | - | 216 | WP_003409878.1 | antitoxin | - |
| CHR52_RS06875 | 1359020..1359316 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| CHR52_RS06880 | 1359317..1359508 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| CHR52_RS06885 | 1359529..1360431 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| CHR52_RS06890 | 1360442..1360792 | + | 351 | WP_106420779.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T79336 WP_003409896.1 NZ_CP022578:1355529-1355825 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T79336 NZ_CP022578:1355529-1355825 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT79336 WP_003409899.1 NZ_CP022578:1355281-1355532 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT79336 NZ_CP022578:1355281-1355532 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |