Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 1145683..1146212 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CHR52_RS05765 Protein ID WP_003411124.1
Coordinates 1145895..1146212 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CHR52_RS05760 Protein ID WP_003411127.1
Coordinates 1145683..1145898 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS05730 1140790..1141569 + 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -
CHR52_RS05735 1141631..1142287 + 657 WP_003411133.1 cell division protein SepF -
CHR52_RS05740 1142449..1142739 + 291 WP_003900476.1 YggT family protein -
CHR52_RS05745 1143007..1143789 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CHR52_RS05750 1143884..1144240 + 357 WP_003411130.1 hypothetical protein -
CHR52_RS05755 1144370..1145428 - 1059 WP_003411129.1 hypothetical protein -
CHR52_RS05760 1145683..1145898 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CHR52_RS05765 1145895..1146212 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHR52_RS05775 1146799..1148145 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CHR52_RS05780 1148193..1148723 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CHR52_RS05785 1148728..1149801 - 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
CHR52_RS05790 1149837..1150118 - 282 WP_003411112.1 hypothetical protein -
CHR52_RS05795 1150115..1151191 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T79328 WP_003411124.1 NZ_CP022578:1145895-1146212 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T79328 NZ_CP022578:1145895-1146212 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT79328 WP_003411127.1 NZ_CP022578:1145683-1145898 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT79328 NZ_CP022578:1145683-1145898 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References