Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 620968..621682 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag CHR52_RS03185 Protein ID WP_003413460.1
Coordinates 620968..621408 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag CHR52_RS03190 Protein ID WP_003413456.1
Coordinates 621395..621682 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS03160 616880..617554 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
CHR52_RS03165 617682..618581 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
CHR52_RS03170 618610..619455 + 846 WP_003413466.1 acyl-CoA thioesterase II -
CHR52_RS03175 619463..620059 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
CHR52_RS03180 620192..620947 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
CHR52_RS03185 620968..621408 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR52_RS03190 621395..621682 - 288 WP_003413456.1 antitoxin VapB41 Antitoxin
CHR52_RS03195 621793..623364 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
CHR52_RS03200 623361..623762 - 402 WP_003899391.1 DUF350 domain-containing protein -
CHR52_RS03205 623844..624275 - 432 WP_003899390.1 DUF4247 domain-containing protein -
CHR52_RS03210 624272..624766 - 495 WP_003413444.1 DUF2617 family protein -
CHR52_RS03215 624777..625397 - 621 WP_003413441.1 DUF4178 domain-containing protein -
CHR52_RS03220 625614..626018 - 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
CHR52_RS03225 626015..626260 - 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T79322 WP_003413460.1 NZ_CP022578:c621408-620968 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T79322 NZ_CP022578:c621408-620968 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT79322 WP_003413456.1 NZ_CP022578:c621682-621395 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT79322 NZ_CP022578:c621682-621395 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References