79319

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 481599..482286 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag CHR52_RS02335 Protein ID WP_003414064.1
Coordinates 481599..481994 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag CHR52_RS02340 Protein ID WP_003414061.1
Coordinates 482020..482286 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS02305 477496..478233 - 738 WP_003414079.1 dienelactone hydrolase family protein -
CHR52_RS02310 478389..479189 + 801 WP_003911953.1 thymidylate synthase -
CHR52_RS02315 479260..479739 + 480 WP_003414073.1 dihydrofolate reductase -
CHR52_RS02320 479813..480232 + 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
CHR52_RS02325 480229..481323 + 1095 WP_003414068.1 restriction endonuclease subunit S -
CHR52_RS02330 481333..481602 + 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
CHR52_RS02335 481599..481994 + 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR52_RS02340 482020..482286 + 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CHR52_RS02345 482283..482699 + 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 -
CHR52_RS02350 482786..484408 + 1623 WP_106420771.1 type I restriction-modification system subunit M -
CHR52_RS02355 484405..484680 + 276 WP_003414055.1 type I restriction endonuclease subunit S -
CHR52_RS02360 484924..485676 + 753 WP_003899465.1 FAD-dependent thymidylate synthase -
CHR52_RS02365 485745..486647 + 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-125)

Antitoxin

(16-56)


Sequences


Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T79319 WP_003414064.1 NZ_CP022578:481599-481994 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

>T79319 NZ_CP022578:481599-481994 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT79319 WP_003414061.1 NZ_CP022578:482020-482286 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT79319 NZ_CP022578:482020-482286 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TF65


Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References