Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 4279676..4280382 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag CHR51_RS20965 Protein ID WP_003417998.1
Coordinates 4279676..4280086 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5R1Z4U0
Locus tag CHR51_RS20970 Protein ID WP_003911013.1
Coordinates 4280083..4280382 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS20950 4275115..4276704 + 1590 WP_003901630.1 IMP dehydrogenase -
CHR51_RS20955 4276724..4277851 + 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
CHR51_RS20960 4277907..4279643 + 1737 WP_003418002.1 cholesterol oxidase -
CHR51_RS20965 4279676..4280086 - 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR51_RS20970 4280083..4280382 - 300 WP_003911013.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CHR51_RS20975 4280417..4281304 - 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
CHR51_RS20980 4281366..4281932 + 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
CHR51_RS20985 4282050..4282754 + 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
CHR51_RS20990 4282771..4284372 + 1602 WP_003417969.1 FAD/NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-65)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T79310 WP_003417998.1 NZ_CP022577:c4280086-4279676 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T79310 NZ_CP022577:c4280086-4279676 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10956.61 Da        Isoelectric Point: 9.2278

>AT79310 WP_003911013.1 NZ_CP022577:c4280382-4280083 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGCKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT79310 NZ_CP022577:c4280382-4280083 [Mycobacterium tuberculosis]
ATGCGTGCTACCGTTGGGCTTGTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGT
TGAAGCCGGCGAGGAACTTGGCGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTT
CTCGCGAAGCCCTGATTGAATCAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCG
GCGCGCGGCTGCAAGCGCACCCTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure
AlphaFold DB A0A5R1Z4U0

References