Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2997814..2998460 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag CHR51_RS14970 Protein ID WP_003403122.1
Coordinates 2998068..2998460 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag CHR51_RS14965 Protein ID WP_003403125.1
Coordinates 2997814..2998071 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS14930 2993132..2993443 - 312 WP_003403164.1 hypothetical protein -
CHR51_RS14935 2993500..2994261 + 762 WP_003403148.1 two-component system response regulator TcrA -
CHR51_RS14940 2994305..2994775 + 471 WP_003403144.1 HAMP domain-containing protein -
CHR51_RS14945 2994889..2995395 + 507 WP_003900973.1 two component system sensor kinase HK1 -
CHR51_RS14950 2995499..2995735 + 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CHR51_RS14955 2995732..2996145 + 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
CHR51_RS14960 2996396..2997631 + 1236 WP_003403128.1 ATP-binding protein -
CHR51_RS14965 2997814..2998071 + 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
CHR51_RS14970 2998068..2998460 + 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
CHR51_RS14975 2998512..3000062 - 1551 WP_003905349.1 MCE family protein -
CHR51_RS14980 3000067..3001275 - 1209 WP_003403114.1 virulence factor Mce family protein -
CHR51_RS14985 3001272..3002798 - 1527 WP_003403112.1 virulence factor Mce family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T79301 WP_003403122.1 NZ_CP022577:2998068-2998460 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T79301 NZ_CP022577:2998068-2998460 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT79301 WP_003403125.1 NZ_CP022577:2997814-2998071 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT79301 NZ_CP022577:2997814-2998071 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References