Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2939125..2939758 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag CHR51_RS14615 Protein ID WP_003403365.1
Coordinates 2939375..2939758 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag CHR51_RS14610 Protein ID WP_003403368.1
Coordinates 2939125..2939280 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS14580 2934242..2936605 - 2364 WP_003901895.1 arylsulfatase AtsD -
CHR51_RS14585 2936719..2936973 + 255 WP_003911263.1 antitoxin VapB7 -
CHR51_RS14590 2936970..2937407 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
CHR51_RS14595 2937517..2937762 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
CHR51_RS14600 2937749..2938057 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
CHR51_RS14605 2938333..2939049 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
CHR51_RS14610 2939125..2939280 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CHR51_RS14615 2939375..2939758 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
CHR51_RS14620 2940146..2941156 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
CHR51_RS14625 2941237..2942742 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
CHR51_RS14630 2942813..2943508 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
CHR51_RS14635 2943501..2943893 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
CHR51_RS14640 2943930..2944466 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T79295 WP_003403365.1 NZ_CP022577:2939375-2939758 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T79295 NZ_CP022577:2939375-2939758 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT79295 WP_003403368.1 NZ_CP022577:2939125-2939280 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT79295 NZ_CP022577:2939125-2939280 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References