Detailed information of TA system TA079286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2306599..2307287
• Replicon: chromosome
• Accession: NZ_CP022577
• Organism: Mycobacterium tuberculosis strain WC078

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: CHR51_RS11330
• Protein ID: WP_003406304.1
• Coordinates: 2306599..2307030 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: CHR51_RS11335
• Protein ID: WP_003406302.1
• Coordinates: 2307027..2307287 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHR51_RS11300	2302426..2302695	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CHR51_RS11305	2302692..2302985	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
CHR51_RS11310	2303042..2303872	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
CHR51_RS11315	2303953..2304813	-	861	WP_003900301.1	hypothetical protein	-
CHR51_RS11325	2304993..2306576	+	1584	WP_009940130.1	PE family protein	-
CHR51_RS11330	2306599..2307030	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
CHR51_RS11335	2307027..2307287	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
CHR51_RS11340	2307363..2308352	-	990	WP_003406301.1	malate dehydrogenase	-
CHR51_RS11345	2308523..2309623	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
CHR51_RS11350	2309700..2310881	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
CHR51_RS11355	2310886..2311710	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T79286 WP_003406304.1 NZ_CP022577:c2307030-2306599 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T79286 NZ_CP022577:c2307030-2306599 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT79286 WP_003406302.1 NZ_CP022577:c2307287-2307027 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT79286 NZ_CP022577:c2307287-2307027 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6