Detailed information of TA system TA079279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1508631..1509334
• Replicon: chromosome
• Accession: NZ_CP022577
• Organism: Mycobacterium tuberculosis strain WC078

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: G0TLK7
• Locus tag: CHR51_RS07635
• Protein ID: WP_003409778.1
• Coordinates: 1509005..1509334 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TLK8
• Locus tag: CHR51_RS07630
• Protein ID: WP_003409780.1
• Coordinates: 1508631..1509008 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHR51_RS07590	1503786..1503977	+	192	WP_003409876.1	hypothetical protein	-
CHR51_RS07595	1503998..1504900	+	903	WP_003899097.1	hypothetical protein	-
CHR51_RS07600	1504911..1505261	+	351	WP_106420779.1	hypothetical protein	-
CHR51_RS07605	1505375..1505557	+	183	WP_003409870.1	hypothetical protein	-
CHR51_RS07610	1505550..1505951	-	402	WP_003409869.1	hypothetical protein	-
CHR51_RS07615	1506018..1506470	+	453	WP_003899095.1	lipoprotein	-
CHR51_RS07620	1506625..1507989	-	1365	WP_003903691.1	HNH endonuclease	-
CHR51_RS07625	1508044..1508634	+	591	WP_003409784.1	SEC-C domain-containing protein	-
CHR51_RS07630	1508631..1509008	+	378	WP_003409780.1	type II toxin-antitoxin system antitoxin MazE5	Antitoxin
CHR51_RS07635	1509005..1509334	+	330	WP_003409778.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CHR51_RS07640	1509544..1510314	-	771	WP_003409775.1	SDR family oxidoreductase	-
CHR51_RS07645	1510311..1511372	-	1062	WP_003899092.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
CHR51_RS07650	1511369..1511884	-	516	WP_003409718.1	flavin reductase family protein	-
CHR51_RS07655	1511881..1512951	-	1071	WP_003902252.1	epoxide hydrolase EphB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11787.82 Da
• Isoelectric Point: 8.5361

>T79279 WP_003409778.1 NZ_CP022577:1509005-1509334 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Nucleotide

• Length: 330 bp

>T79279 NZ_CP022577:1509005-1509334 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13560.07 Da
• Isoelectric Point: 5.1519

>AT79279 WP_003409780.1 NZ_CP022577:1508631-1509008 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Nucleotide

• Length: 378 bp

>AT79279 NZ_CP022577:1508631-1509008 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: G0TLK7

Antitoxin

• AlphaFold DB: G0TLK8