Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1499750..1500294 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CHR51_RS07545 Protein ID WP_003409896.1
Coordinates 1499998..1500294 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CHR51_RS07540 Protein ID WP_003409899.1
Coordinates 1499750..1500001 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS07505 1495477..1496274 - 798 WP_003899101.1 ABC transporter permease -
CHR51_RS07520 1497173..1498393 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CHR51_RS07525 1498426..1498698 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CHR51_RS07530 1498702..1499109 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CHR51_RS07535 1499269..1499763 - 495 WP_003899099.1 hypothetical protein -
CHR51_RS07540 1499750..1500001 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CHR51_RS07545 1499998..1500294 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHR51_RS07550 1500343..1500957 + 615 WP_003901296.1 hypothetical protein -
CHR51_RS07555 1500846..1501391 - 546 WP_003409891.1 SecB-like chaperone -
CHR51_RS07560 1501388..1501837 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
CHR51_RS07565 1501879..1502256 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CHR51_RS21775 1502231..1502752 + 522 WP_003904745.1 hypothetical protein -
CHR51_RS07575 1502726..1503037 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CHR51_RS07580 1503034..1503249 - 216 WP_003409878.1 antitoxin -
CHR51_RS07585 1503489..1503785 + 297 WP_003409877.1 hypothetical protein -
CHR51_RS07590 1503786..1503977 + 192 WP_003409876.1 hypothetical protein -
CHR51_RS07595 1503998..1504900 + 903 WP_003899097.1 hypothetical protein -
CHR51_RS07600 1504911..1505261 + 351 WP_106420779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T79277 WP_003409896.1 NZ_CP022577:1499998-1500294 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T79277 NZ_CP022577:1499998-1500294 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT79277 WP_003409899.1 NZ_CP022577:1499750-1500001 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT79277 NZ_CP022577:1499750-1500001 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References