Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1473378..1474066 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag CHR51_RS07375 Protein ID WP_003409958.1
Coordinates 1473647..1474066 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag CHR51_RS07370 Protein ID WP_003409968.1
Coordinates 1473378..1473638 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS07345 1468869..1469468 - 600 WP_003910883.1 L-lysine exporter -
CHR51_RS07350 1469577..1470488 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
CHR51_RS07355 1470573..1470803 - 231 WP_003409980.1 DUF167 domain-containing protein -
CHR51_RS07360 1470918..1471571 + 654 WP_003409976.1 cutinase Cfp21 -
CHR51_RS07365 1471559..1473235 - 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
CHR51_RS07370 1473378..1473638 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CHR51_RS07375 1473647..1474066 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR51_RS07380 1474291..1475259 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
CHR51_RS07385 1475450..1476136 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
CHR51_RS07390 1476315..1477760 + 1446 WP_106420778.1 APC family permease -
CHR51_RS07395 1477723..1478571 - 849 WP_003901306.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T79276 WP_003409958.1 NZ_CP022577:1473647-1474066 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T79276 NZ_CP022577:1473647-1474066 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT79276 WP_003409968.1 NZ_CP022577:1473378-1473638 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT79276 NZ_CP022577:1473378-1473638 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References