Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 1290158..1290687 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CHR51_RS06475 Protein ID WP_003411124.1
Coordinates 1290370..1290687 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CHR51_RS06470 Protein ID WP_003411127.1
Coordinates 1290158..1290373 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS06440 1285265..1286044 + 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -
CHR51_RS06445 1286106..1286762 + 657 WP_003411133.1 cell division protein SepF -
CHR51_RS06450 1286924..1287214 + 291 WP_003900476.1 YggT family protein -
CHR51_RS06455 1287482..1288264 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CHR51_RS06460 1288359..1288715 + 357 WP_003411130.1 hypothetical protein -
CHR51_RS06465 1288845..1289903 - 1059 WP_003411129.1 hypothetical protein -
CHR51_RS06470 1290158..1290373 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CHR51_RS06475 1290370..1290687 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHR51_RS06485 1291274..1292620 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CHR51_RS06490 1292668..1293198 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CHR51_RS06495 1293203..1294276 - 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
CHR51_RS06500 1294312..1294593 - 282 WP_003411112.1 hypothetical protein -
CHR51_RS06505 1294590..1295666 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T79269 WP_003411124.1 NZ_CP022577:1290370-1290687 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T79269 NZ_CP022577:1290370-1290687 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT79269 WP_003411127.1 NZ_CP022577:1290158-1290373 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT79269 NZ_CP022577:1290158-1290373 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References