Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 565017..565621 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag CHR51_RS02695 Protein ID WP_003414492.1
Coordinates 565229..565621 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag CHR51_RS02690 Protein ID WP_003414495.1
Coordinates 565017..565232 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS02665 560019..560930 + 912 WP_003414505.1 sugar ABC transporter permease -
CHR51_RS02670 560927..561754 + 828 WP_003414504.1 carbohydrate ABC transporter permease -
CHR51_RS02675 561757..563067 + 1311 WP_003414501.1 ABC transporter substrate-binding protein -
CHR51_RS02680 563060..564142 + 1083 WP_003414499.1 ABC transporter ATP-binding protein -
CHR51_RS02685 564221..564970 - 750 WP_003902358.1 enoyl-CoA hydratase -
CHR51_RS02690 565017..565232 + 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CHR51_RS02695 565229..565621 + 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR51_RS02700 565642..565911 + 270 WP_003414489.1 DUF2277 family protein -
CHR51_RS02705 565908..566453 + 546 WP_003910939.1 DUF1802 family protein -
CHR51_RS02710 566758..567645 + 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
CHR51_RS02715 567648..568532 + 885 WP_106420767.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CHR51_RS02720 568804..569349 + 546 WP_014584866.1 DUF1802 family protein -
CHR51_RS02725 569749..570471 + 723 WP_003912014.1 CRISPR-associated endoribonuclease Cas6 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T79257 WP_003414492.1 NZ_CP022577:565229-565621 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T79257 NZ_CP022577:565229-565621 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT79257 WP_003414495.1 NZ_CP022577:565017-565232 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT79257 NZ_CP022577:565017-565232 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References