Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3553500..3554157 Replicon chromosome
Accession NZ_CP022573
Organism Klebsiella pneumoniae strain BIC-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CHX41_RS18105 Protein ID WP_002916310.1
Coordinates 3553747..3554157 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CHX41_RS18100 Protein ID WP_002916312.1
Coordinates 3553500..3553766 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHX41_RS18075 3548656..3550089 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CHX41_RS18080 3550208..3550936 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CHX41_RS18085 3550986..3551297 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CHX41_RS18090 3551461..3552120 + 660 WP_002916317.1 hemolysin III family protein -
CHX41_RS18095 3552271..3553254 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CHX41_RS18100 3553500..3553766 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CHX41_RS18105 3553747..3554157 + 411 WP_002916310.1 protein YgfX Toxin
CHX41_RS18110 3554164..3554685 - 522 WP_002916308.1 flavodoxin FldB -
CHX41_RS18115 3554786..3555682 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CHX41_RS18120 3555705..3556418 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CHX41_RS18125 3556424..3558157 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T79243 WP_002916310.1 NZ_CP022573:3553747-3554157 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T79243 NZ_CP022573:3553747-3554157 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT79243 WP_002916312.1 NZ_CP022573:3553500-3553766 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT79243 NZ_CP022573:3553500-3553766 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References