Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 311735..312371 Replicon chromosome
Accession NZ_CP022572
Organism Neobacillus mesonae strain H20-5

Toxin (Protein)


Gene name mazF Uniprot ID A0A3Q9QS43
Locus tag CHR53_RS01615 Protein ID WP_041967053.1
Coordinates 312021..312371 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3Q9QWB6
Locus tag CHR53_RS01610 Protein ID WP_066400964.1
Coordinates 311735..312016 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR53_RS01590 307977..308558 - 582 WP_127484592.1 rhomboid family intramembrane serine protease -
CHR53_RS01595 308649..308999 + 351 WP_066390536.1 holo-ACP synthase -
CHR53_RS01600 309164..310171 + 1008 WP_127484594.1 outer membrane lipoprotein-sorting protein -
CHR53_RS01605 310293..311456 + 1164 WP_066390544.1 alanine racemase -
CHR53_RS01610 311735..312016 + 282 WP_066400964.1 antitoxin endoai Antitoxin
CHR53_RS01615 312021..312371 + 351 WP_041967053.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CHR53_RS01620 312669..314825 + 2157 WP_180321156.1 RNA-binding transcriptional accessory protein -
CHR53_RS01625 314846..314959 - 114 WP_127484595.1 cortex morphogenetic protein CmpA -
CHR53_RS01630 315057..315536 + 480 WP_127484597.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8998

>T79234 WP_041967053.1 NZ_CP022572:312021-312371 [Neobacillus mesonae]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

>T79234 NZ_CP022572:312021-312371 [Neobacillus mesonae]
TTGATTGTCAAGCGTGGTGACGTATATTTCGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGTCCTGT
ACTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTGATTATTGCAGCGATTACAGCTCAAATTCAAAAAG
CGAAGCTACCTACTCATGTTGAAATTGATGCCAAGCGCTACGGATTTGAACGAGATTCGGTCATCCTGTTAGAGCAAATT
CGTACAATCGATAAACAGCGGTTAACCGATAAAATCACCCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCTT
GCAAGTGAGCCTAGGTCTCATCGAATTCTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10876.40 Da        Isoelectric Point: 7.2029

>AT79234 WP_066400964.1 NZ_CP022572:311735-312016 [Neobacillus mesonae]
VSEPSATTEILVKLPQHLLTELDGFVKQENVNRSEFIYQATKMYLRERKQRQIRESMRRGYMEMAKINLRIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT79234 NZ_CP022572:311735-312016 [Neobacillus mesonae]
GTGTCTGAACCCAGCGCAACTACGGAGATCTTGGTAAAGTTACCGCAACATCTTTTAACTGAACTTGATGGTTTCGTTAA
ACAGGAAAATGTAAACCGTAGTGAATTTATCTACCAAGCAACAAAAATGTATTTACGCGAACGCAAACAGAGACAAATTC
GCGAATCCATGAGACGTGGATACATGGAAATGGCTAAAATCAATCTTAGAATCGCATCAGAAGCATTTCAAGCAGAATAT
GAGGCAGAGCATACTGTTGAACGTCTTGTAAGCGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q9QS43

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9QWB6

References