Detailed information of TA system TA079226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2812909..2813540
• Replicon: chromosome
• Accession: NZ_CP022564
• Organism: Rhizobium leguminosarum bv. viciae strain BIHB 1148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CHY08_RS14515
• Protein ID: WP_094086857.1
• Coordinates: 2813148..2813540 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2A6HZU6
• Locus tag: CHY08_RS14510
• Protein ID: WP_018495663.1
• Coordinates: 2812909..2813151 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHY08_RS14490	2808486..2809766	+	1281	WP_094086853.1	Zn-dependent hydrolase	-
CHY08_RS14495	2809747..2810844	+	1098	WP_094086854.1	DUF917 family protein	-
CHY08_RS14500	2810848..2811177	+	330	WP_094086855.1	TfoX/Sxy family protein	-
CHY08_RS14505	2811194..2812855	+	1662	WP_094086856.1	urocanate hydratase	-
CHY08_RS14510	2812909..2813151	+	243	WP_018495663.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CHY08_RS14515	2813148..2813540	+	393	WP_094086857.1	type II toxin-antitoxin system VapC family toxin	Toxin
CHY08_RS14520	2813568..2813954	-	387	WP_094086858.1	VOC family protein	-
CHY08_RS14525	2813951..2815201	-	1251	WP_094086859.1	MFS transporter	-
CHY08_RS14530	2815291..2816166	+	876	WP_094086860.1	LysR family transcriptional regulator	-
CHY08_RS14535	2816163..2817068	-	906	WP_094086861.1	LysR family transcriptional regulator	-
CHY08_RS14540	2817195..2817959	+	765	WP_094086862.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14640.85 Da
• Isoelectric Point: 7.3178

>T79226 WP_094086857.1 NZ_CP022564:2813148-2813540 [Rhizobium leguminosarum bv. viciae]
MKYLLDANAVIALMKGNERLIAELRKHRPQHFALPAIVAHELFYGAYKSLRTDENLARIDALQFNILEFDRNDARKAGEI
RAALQALGTPIGPYDVLIAGQAAARGLILITRNLREFERVADLQTENWEG

Nucleotide

• Length: 393 bp

>T79226 NZ_CP022564:2813148-2813540 [Rhizobium leguminosarum bv. viciae]
ATGAAGTACCTGCTCGATGCGAATGCCGTCATTGCCCTGATGAAGGGTAATGAGCGCCTCATCGCCGAACTGCGCAAACA
CAGACCGCAACATTTCGCCCTACCGGCAATCGTTGCGCATGAACTCTTCTATGGTGCTTACAAAAGCCTCCGTACCGATG
AGAATCTGGCGCGGATAGATGCGTTGCAATTCAATATCCTGGAATTCGACCGGAACGACGCGCGCAAGGCGGGGGAAATC
CGCGCGGCGCTGCAGGCATTGGGAACGCCGATCGGACCCTATGACGTCCTGATTGCCGGACAGGCCGCCGCCCGCGGCCT
CATCCTGATCACCCGCAATCTGCGTGAGTTCGAGCGCGTGGCTGATTTACAAACCGAGAATTGGGAAGGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9126.19 Da
• Isoelectric Point: 4.3533

>AT79226 WP_018495663.1 NZ_CP022564:2812909-2813151 [Rhizobium leguminosarum bv. viciae]
METAKIFWSGRSQAVRLPKEFRFDGDSVTIRRQGRAIILEPISDDWDWLADVAGPVDQDFATAAEEKPAGQERPELDFFK

Nucleotide

• Length: 243 bp

>AT79226 NZ_CP022564:2812909-2813151 [Rhizobium leguminosarum bv. viciae]
ATGGAAACAGCAAAGATCTTCTGGTCGGGGCGTTCCCAGGCCGTCCGACTGCCCAAGGAATTCCGCTTTGATGGCGATAG
CGTCACCATTCGACGGCAGGGGCGTGCGATCATTCTCGAGCCGATTTCCGATGATTGGGACTGGCTTGCCGACGTGGCCG
GTCCGGTTGATCAGGACTTTGCGACAGCGGCGGAAGAGAAACCTGCCGGGCAGGAGAGACCCGAACTCGACTTCTTCAAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A2A6HZU6