79225

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 37099..37792 Replicon plasmid pSH5-1
Accession NZ_CP022563
Organism Pseudomonas monteilii strain B5

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag CHR29_RS28085 Protein ID WP_003151133.1
Coordinates 37099..37476 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag CHR29_RS28090 Protein ID WP_001172026.1
Coordinates 37457..37792 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR29_RS28075 33292..36321 - 3030 WP_010799689.1 Tn3 family transposase -
CHR29_RS28080 36305..36907 - 603 WP_010465829.1 recombinase family protein -
CHR29_RS28085 37099..37476 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHR29_RS28090 37457..37792 + 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
CHR29_RS28095 37807..38142 + 336 WP_000741275.1 hypothetical protein -
CHR29_RS28100 38166..38492 + 327 WP_000091614.1 hypothetical protein -
CHR29_RS28105 38489..38860 + 372 WP_023103794.1 hypothetical protein -
CHR29_RS28115 39218..39472 - 255 WP_121757888.1 hypothetical protein -
CHR29_RS28120 39548..39742 - 195 WP_121757889.1 hypothetical protein -
CHR29_RS28130 40202..40459 + 258 WP_121757891.1 hypothetical protein -
CHR29_RS28135 40471..40710 + 240 WP_121757892.1 hypothetical protein -
CHR29_RS28140 40707..41096 - 390 WP_121757893.1 hypothetical protein -
CHR29_RS28145 41144..42055 - 912 WP_208722306.1 hypothetical protein -
CHR29_RS28155 42081..42698 - 618 WP_121757935.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..130536 130536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T79225 WP_003151133.1 NZ_CP022563:37099-37476 [Pseudomonas monteilii]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T79225 NZ_CP022563:37099-37476 [Pseudomonas monteilii]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT79225 WP_001172026.1 NZ_CP022563:37457-37792 [Pseudomonas monteilii]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT79225 NZ_CP022563:37457-37792 [Pseudomonas monteilii]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References