Detailed information of TA system TA079220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3773604..3774487
• Replicon: chromosome
• Accession: NZ_CP022561
• Organism: Pseudomonas putida strain B4

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2K4LSC9
• Locus tag: CHN49_RS17590
• Protein ID: WP_012052908.1
• Coordinates: 3773604..3774041 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: I7C3Q7
• Locus tag: CHN49_RS17595
• Protein ID: WP_003250525.1
• Coordinates: 3774038..3774487 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHN49_RS17570	3768985..3769741	-	757	Protein_3351	PAAR domain-containing protein	-
CHN49_RS17575	3769905..3771134	-	1230	WP_121783704.1	acyl-CoA dehydrogenase	-
CHN49_RS17580	3771275..3772198	+	924	WP_004573723.1	LysR family transcriptional regulator	-
CHN49_RS17585	3772392..3773546	+	1155	WP_060537721.1	aminotransferase class V-fold PLP-dependent enzyme	-
CHN49_RS17590	3773604..3774041	-	438	WP_012052908.1	RES family NAD+ phosphorylase	Toxin
CHN49_RS17595	3774038..3774487	-	450	WP_003250525.1	DUF2384 domain-containing protein	Antitoxin
CHN49_RS17600	3774630..3775283	-	654	WP_004573726.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
CHN49_RS17605	3775387..3776310	+	924	WP_121783705.1	LysR family transcriptional regulator	-
CHN49_RS17610	3776359..3777189	+	831	WP_003250518.1	AraC family transcriptional regulator	-
CHN49_RS17615	3777241..3777825	+	585	WP_121783706.1	LysE family transporter	-
CHN49_RS17620	3777865..3779064	-	1200	WP_121783707.1	sugar transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-138)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (33-91)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15944.21 Da
• Isoelectric Point: 5.6016

>T79220 WP_012052908.1 NZ_CP022561:c3774041-3773604 [Pseudomonas putida]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Nucleotide

• Length: 438 bp

>T79220 NZ_CP022561:c3774041-3773604 [Pseudomonas putida]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGTGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGGCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCGACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCTGGCTGGTCTGCTCAGCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACCCCGGACAGCCGCCTGTTCTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16956.46 Da
• Isoelectric Point: 5.7258

>AT79220 WP_003250525.1 NZ_CP022561:c3774487-3774038 [Pseudomonas putida]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Nucleotide

• Length: 450 bp

>AT79220 NZ_CP022561:c3774487-3774038 [Pseudomonas putida]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGTGATTTCGAAATCCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCTGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAGCGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Structures

Toxin

• AlphaFold DB: A0A2K4LSC9

Antitoxin

• AlphaFold DB: I7C3Q7