Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2405179..2405738 Replicon chromosome
Accession NZ_CP022552
Organism Vibrio parahaemolyticus strain MAVP-R

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag BSG32_RS12250 Protein ID WP_005398411.1
Coordinates 2405460..2405738 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag BSG32_RS12245 Protein ID WP_005398409.1
Coordinates 2405179..2405463 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG32_RS12200 2400344..2400661 - 318 WP_021448742.1 hypothetical protein -
BSG32_RS12210 2401304..2401717 - 414 WP_021448743.1 hypothetical protein -
BSG32_RS26125 2401930..2402103 - 174 WP_021448744.1 hypothetical protein -
BSG32_RS12220 2402195..2402752 - 558 WP_021448745.1 hypothetical protein -
BSG32_RS12225 2403510..2403971 - 462 WP_021448746.1 DUF1851 domain-containing protein -
BSG32_RS12230 2404001..2404123 - 123 WP_108702465.1 DUF3265 domain-containing protein -
BSG32_RS12235 2404652..2404990 - 339 WP_021448749.1 hypothetical protein -
BSG32_RS12245 2405179..2405463 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BSG32_RS12250 2405460..2405738 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BSG32_RS12260 2405874..2406233 - 360 WP_021448750.1 DUF2750 domain-containing protein -
BSG32_RS12270 2406372..2407250 - 879 WP_021448752.1 hypothetical protein -
BSG32_RS12280 2407401..2407943 - 543 WP_079765068.1 hypothetical protein -
BSG32_RS12285 2408083..2408340 - 258 WP_033903525.1 hypothetical protein -
BSG32_RS12290 2408455..2408547 - 93 WP_193386937.1 DUF3265 domain-containing protein -
BSG32_RS12295 2409002..2409094 - 93 WP_079765067.1 DUF3265 domain-containing protein -
BSG32_RS12300 2409122..2409580 - 459 WP_025613401.1 hypothetical protein -
BSG32_RS12305 2409608..2409697 - 90 WP_079765069.1 DUF3265 domain-containing protein -
BSG32_RS12310 2410072..2410150 - 79 Protein_2197 DUF3265 domain-containing protein -
BSG32_RS12315 2410179..2410676 - 498 WP_021448757.1 DNA topology modulation protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2332153..2432497 100344
- inside Integron - - 2347816..2431372 83556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T79208 WP_005398411.1 NZ_CP022552:2405460-2405738 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T79208 NZ_CP022552:2405460-2405738 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAAATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT79208 WP_005398409.1 NZ_CP022552:2405179-2405463 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT79208 NZ_CP022552:2405179-2405463 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAATCGAGGTAAGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A347UR22


Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References