Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 105975..106501 Replicon plasmid pMS7884B
Accession NZ_CP022534
Organism Enterobacter hormaechei strain MS7884A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag MS7884_RS26090 Protein ID WP_000323025.1
Coordinates 105975..106262 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag MS7884_RS26095 Protein ID WP_004196370.1
Coordinates 106262..106501 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7884_RS26055 101549..101842 - 294 WP_032663725.1 hypothetical protein -
MS7884_RS26060 102531..102866 - 336 WP_023345479.1 hypothetical protein -
MS7884_RS26065 102909..103700 - 792 WP_032663722.1 N-6 DNA methylase -
MS7884_RS26070 103741..103941 - 201 WP_031494497.1 hypothetical protein -
MS7884_RS26075 104031..104492 - 462 WP_048974901.1 hypothetical protein -
MS7884_RS26080 104552..104866 - 315 WP_023338051.1 hypothetical protein -
MS7884_RS26085 105745..105903 - 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
MS7884_RS26090 105975..106262 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MS7884_RS26095 106262..106501 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
MS7884_RS26105 106752..107117 + 366 WP_009651956.1 hypothetical protein -
MS7884_RS26110 107161..107898 + 738 WP_008460272.1 HupE/UreJ family protein -
MS7884_RS26115 107912..108601 + 690 WP_004196322.1 hypothetical protein -
MS7884_RS26120 108632..110008 - 1377 WP_004196363.1 chromate efflux transporter -
MS7884_RS26125 109965..110942 - 978 WP_004196334.1 chromate resistance protein -
MS7884_RS26495 110972..111164 + 193 Protein_137 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..126208 126208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T79202 WP_000323025.1 NZ_CP022534:c106262-105975 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T79202 NZ_CP022534:c106262-105975 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT79202 WP_004196370.1 NZ_CP022534:c106501-106262 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT79202 NZ_CP022534:c106501-106262 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References