Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4278064..4278803 Replicon chromosome
Accession NZ_CP022532
Organism Enterobacter hormaechei strain MS7884A

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag MS7884_RS20870 Protein ID WP_003857133.1
Coordinates 4278318..4278803 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag MS7884_RS20865 Protein ID WP_003857131.1
Coordinates 4278064..4278330 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7884_RS20845 4273546..4274532 + 987 WP_033487777.1 DUF979 domain-containing protein -
MS7884_RS20850 4274542..4275537 + 996 WP_033487776.1 DUF2891 domain-containing protein -
MS7884_RS20855 4275559..4276941 - 1383 WP_033487775.1 MFS transporter -
MS7884_RS20860 4277071..4278000 + 930 WP_017693416.1 LysR family transcriptional regulator -
MS7884_RS20865 4278064..4278330 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
MS7884_RS20870 4278318..4278803 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
MS7884_RS20875 4278854..4279423 - 570 WP_033487774.1 hypothetical protein -
MS7884_RS20880 4279439..4280404 - 966 WP_033487773.1 hypothetical protein -
MS7884_RS20885 4280673..4282076 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
MS7884_RS20890 4282105..4282737 - 633 WP_001567369.1 hypothetical protein -
MS7884_RS20895 4282812..4283780 + 969 WP_022652343.1 IS5-like element IS903B family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T79198 WP_003857133.1 NZ_CP022532:4278318-4278803 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T79198 NZ_CP022532:4278318-4278803 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT79198 WP_003857131.1 NZ_CP022532:4278064-4278330 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT79198 NZ_CP022532:4278064-4278330 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATTGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References