Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2005015..2005619 Replicon chromosome
Accession NZ_CP022532
Organism Enterobacter hormaechei strain MS7884A

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag MS7884_RS09805 Protein ID WP_071788668.1
Coordinates 2005015..2005200 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag MS7884_RS09810 Protein ID WP_023295606.1
Coordinates 2005215..2005619 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7884_RS09790 2000334..2002172 + 1839 WP_033488026.1 selenocysteine-specific translation elongation factor -
MS7884_RS09795 2002176..2003060 - 885 WP_033488027.1 ROK family protein -
MS7884_RS09800 2003227..2004765 + 1539 WP_033488028.1 aldehyde dehydrogenase AldB -
MS7884_RS09805 2005015..2005200 + 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
MS7884_RS09810 2005215..2005619 + 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MS7884_RS09815 2005675..2007624 - 1950 WP_033488029.1 glycoside hydrolase family 127 protein -
MS7884_RS09820 2007635..2009035 - 1401 WP_033488030.1 MFS transporter -
MS7884_RS09825 2009261..2010079 + 819 WP_033488031.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T79188 WP_071788668.1 NZ_CP022532:2005015-2005200 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T79188 NZ_CP022532:2005015-2005200 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT79188 WP_023295606.1 NZ_CP022532:2005215-2005619 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT79188 NZ_CP022532:2005215-2005619 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACAATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References