Detailed information of TA system TA079187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 1879498..1880114
• Replicon: chromosome
• Accession: NZ_CP022532
• Organism: Enterobacter hormaechei strain MS7884A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MS7884_RS09230
• Protein ID: WP_077266491.1
• Coordinates: 1879743..1880114 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: MS7884_RS09225
• Protein ID: WP_015569912.1
• Coordinates: 1879498..1879740 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS7884_RS09195	1874557..1875357	+	801	WP_003861944.1	DeoR/GlpR family DNA-binding transcription regulator	-
MS7884_RS09200	1875476..1876075	+	600	WP_003861947.1	glucose-1-phosphatase	-
MS7884_RS09205	1876069..1876950	+	882	WP_003861949.1	virulence factor BrkB family protein	-
MS7884_RS09210	1876947..1877384	+	438	WP_015569909.1	D-tyrosyl-tRNA(Tyr) deacylase	-
MS7884_RS09215	1877429..1878370	+	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
MS7884_RS09220	1878379..1879299	-	921	WP_033487982.1	alpha/beta hydrolase	-
MS7884_RS09225	1879498..1879740	+	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
MS7884_RS09230	1879743..1880114	+	372	WP_077266491.1	type II toxin-antitoxin system VapC family toxin	Toxin
MS7884_RS09235	1880154..1881083	-	930	WP_006808712.1	formate dehydrogenase accessory protein FdhE	-
MS7884_RS09240	1881080..1881715	-	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
MS7884_RS09245	1881712..1882614	-	903	WP_014072386.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13723.85 Da
• Isoelectric Point: 6.4882

>T79187 WP_077266491.1 NZ_CP022532:1879743-1880114 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T79187 NZ_CP022532:1879743-1880114 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT79187 WP_015569912.1 NZ_CP022532:1879498-1879740 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT79187 NZ_CP022532:1879498-1879740 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3