Detailed information of TA system TA079186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 1200147..1200723
• Replicon: chromosome
• Accession: NZ_CP022532
• Organism: Enterobacter hormaechei strain MS7884A

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: A0A800YKM1
• Locus tag: MS7884_RS05900
• Protein ID: WP_015572580.1
• Coordinates: 1200436..1200723 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: A0A801DSF4
• Locus tag: MS7884_RS05895
• Protein ID: WP_017694570.1
• Coordinates: 1200147..1200449 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS7884_RS05875	1196444..1196989	+	546	WP_033486712.1	porin	-
MS7884_RS05880	1197165..1198535	-	1371	WP_033486710.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
MS7884_RS05885	1198689..1199441	+	753	WP_033486709.1	AraC family transcriptional regulator	-
MS7884_RS05890	1199480..1200118	+	639	WP_033486708.1	LysE family translocator	-
MS7884_RS05895	1200147..1200449	-	303	WP_017694570.1	BrnA antitoxin family protein	Antitoxin
MS7884_RS05900	1200436..1200723	-	288	WP_015572580.1	BrnT family toxin	Toxin
MS7884_RS05905	1200893..1202164	+	1272	WP_033486707.1	DUF445 domain-containing protein	-
MS7884_RS05910	1202161..1203237	-	1077	WP_015572578.1	DUF2955 domain-containing protein	-
MS7884_RS05915	1203227..1204294	-	1068	WP_026080654.1	HlyD family secretion protein	-
MS7884_RS05920	1204291..1204761	-	471	WP_033486706.1	MarR family transcriptional regulator	-
MS7884_RS05925	1204911..1205630	-	720	WP_050515874.1	winged helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (32-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11296.81 Da
• Isoelectric Point: 7.3587

>T79186 WP_015572580.1 NZ_CP022532:c1200723-1200436 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Nucleotide

• Length: 288 bp

>T79186 NZ_CP022532:c1200723-1200436 [Enterobacter hormaechei]
ATGCCTATAGAGTATGAGTGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGCGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11482.13 Da
• Isoelectric Point: 10.4094

>AT79186 WP_017694570.1 NZ_CP022532:c1200449-1200147 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT79186 NZ_CP022532:c1200449-1200147 [Enterobacter hormaechei]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGCGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA