Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 705782..706402 Replicon chromosome
Accession NZ_CP022532
Organism Enterobacter hormaechei strain MS7884A

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag MS7884_RS03550 Protein ID WP_015571250.1
Coordinates 706184..706402 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag MS7884_RS03545 Protein ID WP_006809850.1
Coordinates 705782..706156 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7884_RS03535 700909..702102 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MS7884_RS03540 702125..705271 + 3147 WP_033486650.1 multidrug efflux RND transporter permease subunit -
MS7884_RS03545 705782..706156 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
MS7884_RS03550 706184..706402 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
MS7884_RS03555 706611..707162 + 552 WP_015571251.1 maltose O-acetyltransferase -
MS7884_RS03560 707279..707746 + 468 WP_023296041.1 hypothetical protein -
MS7884_RS03565 707718..709178 - 1461 WP_033486652.1 PLP-dependent aminotransferase family protein -
MS7884_RS03570 709280..709990 + 711 WP_033486653.1 GNAT family N-acetyltransferase -
MS7884_RS03575 709987..710127 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MS7884_RS03580 710130..710390 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T79185 WP_015571250.1 NZ_CP022532:706184-706402 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T79185 NZ_CP022532:706184-706402 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACTCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT79185 WP_006809850.1 NZ_CP022532:705782-706156 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT79185 NZ_CP022532:705782-706156 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References