Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
| Location | 78446..79243 | Replicon | chromosome |
| Accession | NZ_CP022532 | ||
| Organism | Enterobacter hormaechei strain MS7884A | ||
Toxin (Protein)
| Gene name | ataT | Uniprot ID | - |
| Locus tag | MS7884_RS00440 | Protein ID | WP_033487261.1 |
| Coordinates | 78446..78967 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A331QJY7 |
| Locus tag | MS7884_RS00445 | Protein ID | WP_015570876.1 |
| Coordinates | 78974..79243 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MS7884_RS00410 | 74044..74733 | + | 690 | WP_023296288.1 | pyrimidine utilization protein B | - |
| MS7884_RS00415 | 74745..75131 | + | 387 | WP_033487260.1 | pyrimidine utilization protein C | - |
| MS7884_RS00420 | 75139..75939 | + | 801 | WP_023296287.1 | pyrimidine utilization protein D | - |
| MS7884_RS00425 | 75949..76539 | + | 591 | WP_017693662.1 | malonic semialdehyde reductase | - |
| MS7884_RS00430 | 76552..77043 | + | 492 | WP_015570873.1 | pyrimidine utilization flavin reductase protein F | - |
| MS7884_RS00435 | 77065..78387 | + | 1323 | WP_032670921.1 | pyrimidine utilization transport protein G | - |
| MS7884_RS00440 | 78446..78967 | - | 522 | WP_033487261.1 | GNAT family N-acetyltransferase | Toxin |
| MS7884_RS00445 | 78974..79243 | - | 270 | WP_015570876.1 | DUF1778 domain-containing protein | Antitoxin |
| MS7884_RS00450 | 79317..80216 | - | 900 | WP_033487262.1 | DMT family transporter | - |
| MS7884_RS00455 | 80333..80503 | - | 171 | WP_001273664.1 | general stress protein | - |
| MS7884_RS00460 | 80894..81490 | + | 597 | WP_033487263.1 | NAD(P)H:quinone oxidoreductase | - |
| MS7884_RS00465 | 81509..81736 | + | 228 | WP_032670920.1 | YccJ family protein | - |
| MS7884_RS00470 | 81769..83010 | - | 1242 | WP_033487264.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| MS7884_RS00475 | 83165..83329 | + | 165 | WP_072015914.1 | helix-turn-helix transcriptional regulator | - |
| MS7884_RS00480 | 83339..83698 | - | 360 | WP_017384779.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19453.18 Da Isoelectric Point: 7.4318
>T79183 WP_033487261.1 NZ_CP022532:c78967-78446 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQS
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQS
Download Length: 522 bp
>T79183 NZ_CP022532:c78967-78446 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGTTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGTCGTGA
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGTTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGTCGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10247.75 Da Isoelectric Point: 5.8836
>AT79183 WP_015570876.1 NZ_CP022532:c79243-78974 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT79183 NZ_CP022532:c79243-78974 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|