Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 418722..419989 Replicon chromosome
Accession NZ_CP022529
Organism Labrenzia sp. VG12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CHH27_RS01945 Protein ID WP_094070080.1
Coordinates 418722..419342 (-) Length 207 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CHH27_RS01950 Protein ID WP_094070081.1
Coordinates 419414..419989 (-) Length 192 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHH27_RS01925 415297..415758 - 462 WP_094070076.1 Lrp/AsnC family transcriptional regulator -
CHH27_RS01930 415864..417330 + 1467 WP_094070077.1 aminotransferase class V-fold PLP-dependent enzyme -
CHH27_RS01935 417343..418131 + 789 WP_094070078.1 class II glutamine amidotransferase -
CHH27_RS01940 418238..418603 - 366 WP_094070079.1 STAS/SEC14 domain-containing protein -
CHH27_RS01945 418722..419342 - 621 WP_094070080.1 HD domain-containing protein Toxin
CHH27_RS01950 419414..419989 - 576 WP_094070081.1 helix-turn-helix domain-containing protein Antitoxin
CHH27_RS01955 420054..420680 - 627 WP_094070082.1 chloramphenicol acetyltransferase -
CHH27_RS01960 421077..421910 + 834 WP_094074460.1 phosphonate ABC transporter ATP-binding protein -
CHH27_RS01965 421968..422885 + 918 WP_094070083.1 phosphonate ABC transporter substrate-binding protein -
CHH27_RS01970 422935..423807 + 873 WP_208988437.1 phosphonate ABC transporter, permease protein PhnE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(28-162)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-63)


Sequences

Toxin        


Download         Length: 207 a.a.        Molecular weight: 23268.37 Da        Isoelectric Point: 4.7165

>T79180 WP_094070080.1 NZ_CP022529:c419342-418722 [Labrenzia sp. VG12]
MDKTLHQNEPAAISCERLTGLLAFLQAAEQLKDTLRSGTTRSGRPESTAEHSWRLALMVLVFEKDLPGLDIPRLLKLCLV
HDLGEAISGDVPAPSQTAEDDREERERRDFRSLCATLPQDTASELLALWNEYAAAETAEACLAKAFDKLETMLQHLLMPE
GDVIFYEFNLHYGRDRTDWSPLTRQIREIIDGRTSERLGTMDRKLG

Download         Length: 621 bp

>T79180 NZ_CP022529:c419342-418722 [Labrenzia sp. VG12]
ATGGACAAAACACTTCACCAAAATGAACCCGCAGCTATCTCCTGCGAAAGACTGACCGGCCTTCTTGCCTTCCTCCAGGC
TGCAGAGCAGTTGAAAGACACGCTGCGCTCCGGGACGACACGCAGCGGCCGGCCCGAAAGCACGGCCGAGCACAGTTGGC
GCCTCGCACTGATGGTGCTTGTTTTTGAGAAGGACCTGCCAGGTCTCGACATACCCAGACTGTTGAAACTGTGCCTTGTC
CATGACCTTGGCGAGGCTATCTCCGGTGACGTCCCCGCCCCTTCGCAAACGGCTGAAGATGATCGTGAGGAACGGGAACG
TCGGGACTTTCGCTCCCTGTGTGCAACTCTCCCGCAGGACACCGCGTCCGAATTGCTGGCGCTTTGGAATGAGTATGCAG
CGGCGGAGACAGCTGAAGCCTGCCTTGCCAAGGCCTTCGACAAGCTGGAAACGATGTTACAGCACCTTCTGATGCCGGAG
GGTGACGTGATCTTTTACGAATTCAACCTGCATTATGGCCGCGACAGGACCGATTGGTCTCCCCTCACGCGCCAGATCCG
CGAGATCATCGACGGCAGGACATCCGAACGCCTCGGCACAATGGACCGAAAGCTGGGGTAA

Antitoxin


Download         Length: 192 a.a.        Molecular weight: 21464.49 Da        Isoelectric Point: 10.0364

>AT79180 WP_094070081.1 NZ_CP022529:c419989-419414 [Labrenzia sp. VG12]
MPTVTAVLQTSLGPSLRRWRALNRVKQEVLAHELGVSQARISRWESGHAQPDGRHLLKITQLLRARPSTAADRALLDLVS
RSSDSVHLVCDLTHRLLAMSAGREKERRAPVSEYLNRPLWRFASDGIRAAEQSLAENGWYEPDGPDILYKTERVEFPEMT
IPECSVRISRLPLADGSFARLVRADRTSAMS

Download         Length: 576 bp

>AT79180 NZ_CP022529:c419989-419414 [Labrenzia sp. VG12]
ATGCCCACTGTAACTGCCGTTCTCCAGACCAGTCTCGGCCCATCTCTTCGGCGATGGCGGGCGCTGAACCGCGTCAAGCA
AGAGGTGCTGGCGCATGAGCTCGGCGTCTCCCAGGCGCGGATCTCCAGATGGGAAAGTGGCCATGCCCAGCCTGACGGCC
GGCACCTTCTGAAAATCACCCAGCTGCTGCGCGCACGCCCCTCAACTGCGGCGGACCGGGCGTTGCTTGACCTTGTGAGC
CGCTCGTCCGATTCCGTCCACCTCGTCTGTGACCTGACCCACAGGCTGCTGGCAATGTCAGCTGGCCGCGAGAAGGAACG
GCGCGCTCCGGTGTCGGAATACTTGAATCGGCCTTTGTGGCGCTTTGCCTCCGACGGCATCCGGGCGGCCGAGCAATCGC
TGGCAGAAAATGGCTGGTACGAGCCGGACGGTCCGGACATCCTGTACAAAACCGAGCGGGTCGAGTTTCCCGAGATGACC
ATTCCGGAATGCTCTGTCCGTATCTCCCGTCTTCCCCTCGCCGACGGCAGCTTTGCACGACTGGTGCGTGCGGATCGTAC
ATCTGCGATGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References