Detailed information of TA system TA079179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2290022..2290654
• Replicon: chromosome
• Accession: NZ_CP022527
• Organism: Neisseria sp. KEM232

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: L1NXN1
• Locus tag: CGZ77_RS11420
• Protein ID: WP_009425232.1
• Coordinates: 2290022..2290420 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CGZ77_RS11425
• Protein ID: WP_051040403.1
• Coordinates: 2290421..2290654 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGZ77_RS11410	2285749..2288958	-	3210	WP_009425229.1	carbamoyl-phosphate synthase large subunit	-
CGZ77_RS11415	2288974..2289774	-	801	WP_009425230.1	toll/interleukin-1 receptor domain-containing protein	-
CGZ77_RS11420	2290022..2290420	-	399	WP_009425232.1	type II toxin-antitoxin system VapC family toxin	Toxin
CGZ77_RS11425	2290421..2290654	-	234	WP_051040403.1	antitoxin	Antitoxin
CGZ77_RS11430	2290741..2291241	-	501	WP_009425234.1	CAP domain-containing protein	-
CGZ77_RS11435	2291449..2293047	-	1599	WP_009425235.1	L-lactate permease	-
CGZ77_RS11440	2293735..2295180	-	1446	WP_009425239.1	iron-sulfur cluster-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14957.24 Da
• Isoelectric Point: 8.0631

>T79179 WP_009425232.1 NZ_CP022527:c2290420-2290022 [Neisseria sp. KEM232]
MLKYMLDTNIVIYVMKRRPLEVLETFNRHAARLCVSSITAAELYYGAEKSAFPERNLQAAEDFLSRLQVLPYGIKAAAHF
GNIRAELGKTGRLIGENDLHIAAHARSEGLVLVSNNLREFERVDGLRLENWV

Nucleotide

• Length: 399 bp

>T79179 NZ_CP022527:c2290420-2290022 [Neisseria sp. KEM232]
ATGCTCAAATATATGCTCGACACCAATATCGTGATTTATGTGATGAAGCGCCGTCCGCTTGAAGTTTTGGAAACCTTCAA
CCGCCATGCCGCGCGTTTGTGTGTCAGCAGCATTACCGCCGCCGAGCTGTACTACGGCGCGGAAAAAAGCGCGTTTCCCG
AACGCAACCTGCAAGCCGCCGAAGATTTTTTATCCCGCCTGCAAGTGCTGCCCTACGGCATCAAAGCCGCCGCCCACTTC
GGCAATATCCGCGCCGAACTGGGAAAAACCGGGCGGCTGATTGGCGAAAACGATCTGCATATCGCCGCCCATGCCCGCAG
CGAAGGGCTGGTTTTGGTCAGCAACAACCTGCGCGAGTTTGAGCGCGTGGACGGTTTGCGTTTGGAAAACTGGGTGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8342.32 Da
• Isoelectric Point: 4.4201

>AT79179 WP_051040403.1 NZ_CP022527:c2290654-2290421 [Neisseria sp. KEM232]
MTRVSLSFAADGQSVRLPEQAQFGGNVKTVDVRVVGNERIISPAAQVWDSFFAAGSGVSEDFMAVRETAVQPEREQL

Nucleotide

• Length: 234 bp

>AT79179 NZ_CP022527:c2290654-2290421 [Neisseria sp. KEM232]
ATGACACGAGTCAGTTTGTCATTCGCCGCCGACGGCCAAAGCGTCAGGCTGCCCGAGCAGGCGCAGTTTGGCGGCAATGT
GAAGACTGTTGATGTGCGCGTGGTCGGCAACGAGCGCATCATCAGCCCCGCCGCGCAGGTTTGGGACAGCTTTTTTGCCG
CAGGCAGCGGCGTCAGCGAAGATTTTATGGCCGTGCGGGAAACCGCCGTGCAGCCCGAACGGGAGCAGCTGTAA

Structures

Toxin

• AlphaFold DB: L1NXN1